African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12496

Full Length Research Paper

Effect of propionate on the production of natamycin with Streptomyces gilvosporeus XM-172

Keju Jing*, Xiaobin Hao and Yinghua Lu
Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China.
Email: [email protected]

  •  Accepted: 07 July 2011
  •  Published: 31 August 2011

Abstract

This study described the influence of feeding short-chain fatty acids and alcohols on natamycin production in the glucose basal medium, produced by Streptomyces gilvosporeus XM-172. The highest natamycin production was obtained with feeding propionate as compared to other precursors. The optimal propionate concentration and feeding time were 6 g L-1 and early log phase, respectively. This optimal propionate feeding strategy led to a natamycin production of 6.72 g L-1, which was nearly 85% higher than that of the control. It was firstly revealed that propionate could greatly promote natamycin biosynthesis by S. gilvosporeus.

 

Key words: Precursor, propionate, natamycin production, Streptomyces gilvosporeus XM-172.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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