African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12501

Short Communication

Enhanced production of glucose oxidase from UV-mutant of Aspergillus niger

Muhammad Ramzan1 and Tahir Mehmood2
1Department of Chemistry and Biochemistry, University of Agriculture, Faisalabad-38040, Pakistan. 2Department of Chemistry, University of Sargodha-40100, Pakistan.    
Email: [email protected]

  •  Published: 19 January 2008

Abstract

UV rays were used as mutagen in wild type strain of Aspergillus niger for enhanced production of glucose oxidase. After mutangenization and selection, mutant A. nigerstrains, resistant to 2-deoxy-D-glucose were obtained. The mutants showed 1.57 and 1.98 fold increase in activities of extra and intra cellular glucose oxidase respectively in comparison with the parental strain. Out of 6 mutants, mutant U-6 was selected as the best producer of glucose oxidase after 36 h of fermentation using black strap molasses as substrate.

 

Key words: Aspergillus niger, glucose oxidase, mutagenesis, UV.

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