African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12504

Full Length Research Paper

Cytotoxic, antibacterial activity and physico-chemical properties of some acid catalyzed Schiff bases

Malik Amanullah1, Sher Khan Sadozai1, Wajid Rehman2*, Zonera Hassan3Abdur Rauf1 and Muhammad Iqbal1
  1Department of Chemistry Gomal University Dera Ismail Khan, Pakistan. 2Department of Chemistry, Hazara University, Mansehra, Pakistan. 3Department of Biochemistry, Hazara University, Mansehra, Pakistan
Email: [email protected]

  •  Published: 10 January 2010

Abstract

 

Some novel Schiff bases have been derived using aromatic aldehydes and aromatic amine in ethanol under acidic conditions. The geometry of these Schiff bases was established using various spectroscopic methods like infrared (IR), nuclear magnetic resonance (NMR) and mass spectrometry. The conductivity studies reveal the non electrolytic behavior of Schiff bases. The synthesized Schiff bases were tested in vitro with the aim of identifying novel lead compounds active against various types of bacteria and shrimps.

 

Key words: Acid catalyzed, Schiff bases, NMR, antibacterial activity, brine shrimp.

Abbreviation

 

Abbreviations: FTIR, Fourier transform infrared; IR, infrared; NMR, nuclear magnetic resonance; TLC, thin layer chromatography; DMSO, dimethyl sulfoxide;GC-MS, gas chromatography-mass spectrometry; MIC, minimum inhibitory concentration.

 

Copyright © 2025 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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