African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12501

Full Length Research Paper

Inhibitory activity of a water-soluble morin derivative on phosphatase of regenerating liver-3

  Liu Wen1, Xiao De-Qian2, Liang Nian-Ci1,3 and He Tai-Ping1,4*      
  1Institute of Biochemistry and Molecular Biology, Guangdong Medical College, No.2 Wenming Road, Zhanjiang 524023, Guangdong, China. 2Department of Clinical Biochemistry, School of Laboratory Medicine, Guangdong Medical College, No.1 Xincheng Road, Dongguan 523808, Guangdong, China. 3Guangdong Key Laboratory for Research and Development of Natural Drugs, Zhanjiang 524023, Guangdong, China. 4Department of Nutrition and Food Hygiene, School of Public Health, Guangdong Medical College, Zhanjiang 524023, Guangdong, China.
Email: [email protected]

  •  Accepted: 14 February 2012
  •  Published: 01 March 2012

Abstract

 

Morin sulphate, a novel water-soluble derivative was semi-synthesized from morin as a parent molecule. The aim of the current study was to examine the inhibitory activity of morin sulphate on the phosphatase of regenerating liver-3 (PRL-3), and its role in the metastatic potency of high metastatic ovarian carcinoma cell line (HO-8910PM) in vitro. Morin sulphate significantly inhibited PRL-3 activity in a dose-dependent manner with an IC50 value of 1.06 µM. Furthermore, morin sulphate inhibited the invasion and migration of HO-8910PM cells, suggesting that it is a PRL-3 inhibitor.

 

Key words: Protein tyrosine phosphatases, PRL-3 protein, enzyme inhibitors, morin hydrate, neoplasms, metastasis.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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