African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12501

Full Length Research Paper

Susceptibility of imipenem-resistant Pseudomonas aeruginosa to flavonoid glycosides of date palm (Phoenix dactylifera L.) tamar growing in Al Madinah, Saudi Arabia

  Samy Selim1,2*, Sahar El Alfy2, Meshref Al-Ruwaili1, Amin Abdo3 and Soad Al Jaouni4
  1Microbiology Laboratory, Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Al-Jouf University, P.O. 2014, Sakaka, Saudi Arabia. 2Microbiology Section, Botany Department, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt. 3Gomohory Hospital, Ministry of Health, Sana'a, Yemen. 4Department of Hematology, Faculty of Medicine, King Abdulaziz University, P.O. Box 80215, Jeddah 21589, Saudi Arabia.
Email: [email protected].

  •  Published: 05 January 2012

Abstract

 

The fruits of the date palm (Phoenix dactylifera L.) are consumed throughout the world and are an important part of the diet in the Middle East. Dates at tamar stage contain a wide array of flavones, but little is known about the antimicrobial of flavonoid glycosides compounds in dates. In this study, we evaluated the antimicrobial of flavonoid glycosides extracted from the date fruits grown in Al Madinah, Saudi Arabia at full ripe stage against imipenem-resistant P. aeruginosa (IRP). A chloroform fraction prepared from the date showed potent inhibitory activity against IRP. The active compounds were elucidated to be quercetin, luteolin, and apigenin based on their spectral analysis. Flavonoid glycosides showed significant antibacterial activities against IRP. These compounds represent novel leads, and future studies may allow the development of a pharmacologically acceptable antimicrobial agent or class of agents.

 

Key words: Phoenix dactylifer, flavonoid glycosides, imipenem-resistant P. aeruginosa.