African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12500

Review

Geographical evolution of the CTX-M β-lactamase – an update

Govinden, U.1*, Mocktar, C.1, Moodley, P.2, Sturm, A. W.2 and Essack S.Y.1
1School of Pharmacy and Pharmacology, University of Kwazulu Natal, Durban, 4000. 2Nelson R Mandela, School of Medicine, Department of Medical Microbiology, University of Kwazulu Natal, Durban, 4000.
Email: [email protected]

  •  Accepted: 23 January 2007
  •  Published: 02 April 2007

Abstract

The CTX-M- type extended spectrum β-lactamases (ESBLs) that preferentially hydrolyze cefotaxime are emerging globally and comprise of more than 50 enzymes.The emergence of novel CTX-M β-lactamases in several countries is noted as opposed to the transfer of established CTX-M genes from one country to another, suggestive of a de novo dissemination of CTX-M genes.

 

Key words: CTX-M β-lactamase, geographic evolution, epidemiology.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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