Abstract

There are numerous arguments for the predictive factors of positive prostate biopsies differing according to race and region. This retrospective study aimed to determine predictive factors for a positive prostate biopsy in Chinese men. Data were collected from 1608 men who underwent a prostate biopsy for suspected prostate cancer. Variables analyzed included age, prostate specific antigen (PSA) level, prostate volume and PSA density (PSAD). Logistic regression analysis estimated relative risk, 95% confidence intervals and p values. Overall, 598 (37.19%) of the 1608 biopsied had prostate cancer. Independent predictors of a positive biopsy result include advanced age, elevated PSA levels, small prostate volume and increased PSAD. Our study showed significant predictors for positive prostate biopsy in Chinese men and a combination of age, PSA, prostate volume and PSAD better defined the probability of a positive biopsy than any factor alone. In the future, we may be able to use our finding to create a nomogram for predicting positive prostate biopsy in Chinese men.

Key words: Prostate biopsy, PSA, prostate volume, prostatic neoplasms.

Abbreviation

PCa, Prostate cancer; PSA, prostate specific antigen; BPH, Benign prostatic hyperplasia; TRUS, transrectal ultrasound; DRE, digital rectal examination;PSAD, PSA density.