African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 425


The significance of artemisinin in roll back malaria partnership programmes and cancer therapy

Obimba, Kelechukwu Clarence
  • Obimba, Kelechukwu Clarence
  • Department of Biochemistry, College of Natural and Applied Sciences, Michael Okpara University of Agriculture Umudike. Abia State, Nigeria.
  • Google Scholar

  •  Received: 03 November 2011
  •  Accepted: 13 December 2011
  •  Published: 30 January 2012


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Bosman A, Mendis KN (2007). A major Transition in Malarial Treatment: The adoption and deployment of Artemisinin-based combination Therapies. Am. J. Trop. Med. Hyg., 77(6): 193-197.



Covello PS, Teoh KH, Polichuk DR, Reed DW, Nowak G (2007). Functional genomics and the biosynthesis of artemisinin. Phytochem., 6814 : 1864-1871.



Efferth T, Sauerbrey A, Olbrich A, Gebhart E, Rauch P, Weber HO, Hengstler JG, Halatsch ME, Volm M, Tew KD, Ross DD, Funk JO (2003). Molecular modes of action of artesunate in tumor cell lines. Mol. Pharmacol., 64: 382-394.



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Firestone GL, Sundar SN (2009). Anticancer activities of artemisinin and its bioactive derivatives. Expert. Rev. Mol. Med., 11:e32.



Gao N, Budhraja A, Cheng S, Liu EH, Huang C, Chen J, Yang Z, Chen D, Zhang Z, Shi X (2011). Interruption of the MEK/ERK signaling cascade promotes dihydroartemisinin-induced apoptosis in vitro and in vivo. Apoptosis. 16(5): 511-523.



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Jambou R, Legrand E, Niang M, Khim N, Lim P, Volney B, Ekala MT, Bouchier C, Esterre P, Fandeur T, Mercereau-Puijalon O (2005). Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6. Lancet, 366: 1960-1963.



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Lu JJ, Meng LH, Cai YJ, Chen Q, Tong LJ, Lin LP, Ding J (2008). Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species. Cancer Biol. Ther., 7: 1017-1023.



Martin VJ, Yoshikuni Y Keasling JD (2001). The in vivo synthesis of plant sesquiterpenes by Escherichia coli. Biotech. Bioeng., 7: 497-503.



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Mutabingwa TK, Anthony D, Heller A (2005). Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial. Lancet 365(9469): 1474-1480.



Ohgami Y, Elstad CA, Chung E, Shirachi DY, Quock RM, Lai HC (2010). Effect of Hyperbaric Oxygen on the Anticancer Effect of Artemisinin on Molt-4 Human Leukemia Cells. Intl. J. Cancer Res. Treatment. 30(11): 4467-4470.



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Sutherland CJ, Ord R, Dunyo S, Jawara M, Drakeley CJ, Alexander N, Coleman R, Pinder M, Walraven G, Targett GA (2005). Reduction of malaria transmission to Anopheles mosquitoes with a six-dose regimen of co-artemether. PLoS Med., 2: e92.



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World Health Organization. (2003). Procurement, quality and sourcing project: access to artemisinin-based combination antimalarial drugs of acceptable quality. Geneva, World Health Organization.



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