African Journal of
Medical and Health Sciences

OFFICIAL PUBLICATION OF THE FEDERAL TEACHING HOSPITAL, ABAKALIKI, NIGERIA
  • Abbreviation: Afr. J. Med. Health Sci.
  • Language: English
  • ISSN: 2384-5589
  • DOI: 10.5897/AJMHS
  • Start Year: 2017
  • Published Articles: 64

Full Length Research Paper

Anaemia and associated factors in multidrug-resistant tuberculosis patients at initiation of treatment in the Republic of Guinea

Aboubacar Sidiki Magassouba
  • Aboubacar Sidiki Magassouba
  • Public Health Chair, Gamal Abdel Nasser University in Conakry; International Union against Tuberculosis and Lung Disease, Guinea.
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Mamadi Diakite
  • Mamadi Diakite
  • Department of Hematology, Ignace Deen National Hospital, Guinea.
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Younoussa Sylla
  • Younoussa Sylla
  • Public Health Chair, Gamal Abdel Nasser University in Conakry; International Union against Tuberculosis and Lung Disease, Guinea.
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Almamy Amara Toure
  • Almamy Amara Toure
  • Mafereinyah Research Center, Guinea.
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Boubacar Djelo Diallo
  • Boubacar Djelo Diallo
  • Department of Pneumology, Ignace Deen National Hospital, Guinea.
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Souleymane Camara
  • Souleymane Camara
  • National Tuberculosis Control Program, Guinea.
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Fodé Fidel oularé
  • Fodé Fidel oularé
  • Multidrug-resistant tuberculosis treatment centre of Ignace Deen, Guinea.
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Almamy Camara
  • Almamy Camara
  • Multidrug-resistant tuberculosis treatment centre of Ignace Deen, Guinea.
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Aboubacar Camara
  • Aboubacar Camara
  • Multidrug-resistant tuberculosis treatment centre of Ignace Deen, Guinea.
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Niouma Nestor Lemo
  • Niouma Nestor Lemo
  • Public Health Chair, Gamal Abdel Nasser University in Conakry; International Union against Tuberculosis and Lung Disease, Guinea.
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Adama Marie Bangoura
  • Adama Marie Bangoura
  • National Tuberculosis Control Program, Guinea.
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  •  Received: 08 December 2021
  •  Accepted: 21 July 2022
  •  Published: 31 August 2022

Abstract

Multidrug-resistant tuberculosis is involved in multiple haematological manifestations, including anaemia. The objective was to determine the prevalence of anaemia and associated factors in patients with drug-resistant TB. This was a 3-year longitudinal cohort study of patients affected by multidrug-resistant tuberculosis followed up monthly for 9 months by the WHO standardized short treatment regimen in three large multidrug-resistant tuberculosis centres in Conakry. Data were collected using a drug-resistant TB registry form. frequencies were used, means (standard deviation) for data description, and multivariate logistic regression to find factors associated with anaemia. A total of 218 patients were included, mostly men (68.3%), the mean age was 34 years, living mainly in urban areas (77.5%). 23% were seropositive for HIV, 82.6% of patients had already been infected. Anaemia was noted in 71% of patients. In multivariate analysis, HIV-positive patients were more likely to have anaemia (p_value <0.001) as well as vomiting (p_value = 0.049). The results of the biology showed an influence of the leukocyte level (p_value = 0.006) and the platelet count (p_value = 0.043). Anaemia is frequent in multidrug-resistant tuberculosis, serological status, antecedents of antituberculosis treatment, functional and laboratory signs were the factors associated with anaemia.

Key words: Anaemia, TBMR, Guinea.