African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5210

Short Communication

Antifungal metabolites from the fermentation broth of plant endophytic fungus Pestalotiopsis photiniae

  Xiao-Long Yang1,2,*, Zhuang-Zhuang Li1, Hai-Ying Li1, and Zhi-Qin Liu1
  1College of Pharmaceutical Science, Hebei University, Baoding 071002, China. 2Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Email: [email protected]

  •  Accepted: 09 January 2013
  •  Published: 05 July 2013



Pestalotiopsis genus, one of the most potential resources for biological active compounds, can produce most interesting compounds with broad activity spectrum. In the course of our research on bioactive metabolites of the genus Pestalotiopsis in China, the present study was undertaken to investigate the bioactive chemical constituents of the culture broth of Pestalotiopsis photiniae isolated from the branch of Podocarpus macrophyllus in Hainan, People’s Republic of China, and this led to the isolation of three know compounds named guaidiol (1), ethyl everninate (2) and 10-norparvulenone (3).Compounds 1-3 displayed antifungal activity against three fungal strains includingGibberelle zeaeBotrytis cinerea, and Phytophthora nicotianae, with minimum inhibition concentration (MIC) values from 25.0 to 3.1 μg/ml (the positive control ketoconazole showed MIC values from 6.3 to 3.1 μg/ml).


Key words: Entophytic fungi, Pestalotiopsis photiniae, antifungal activity.