Pestalotiopsis genus, one of the most potential resources for biological active compounds, can produce most interesting compounds with broad activity spectrum. In the course of our research on bioactive metabolites of the genus Pestalotiopsis in China, the present study was undertaken to investigate the bioactive chemical constituents of the culture broth of Pestalotiopsis photiniae isolated from the branch of Podocarpus macrophyllus in Hainan, People’s Republic of China, and this led to the isolation of three know compounds named guaidiol (1), ethyl everninate (2) and 10-norparvulenone (3).Compounds 1-3 displayed antifungal activity against three fungal strains includingGibberelle zeae, Botrytis cinerea, and Phytophthora nicotianae, with minimum inhibition concentration (MIC) values from 25.0 to 3.1 μg/ml (the positive control ketoconazole showed MIC values from 6.3 to 3.1 μg/ml).
Key words: Entophytic fungi, Pestalotiopsis photiniae, antifungal activity.
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