African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5210


New chimeric anti-tubercular dendrimers with self-delivering property

Ghazaleh Ghavami and Soroush Sardari*
Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute, #69 Pasteur Ave., Tehran 13164, Iran.
Email: [email protected]

  •  Accepted: 15 July 2011
  •  Published: 09 September 2011


Tuberculosis is the second lethal infectious disease caused by Mycobacterium species. This pathogens could cause severe disease like tuberculosis and leprosy in human. Today there are a number of anti tuberculosis agents utilized in treatment of this disease but multiple drug resistance is one of the major problems that end to failure in treatment. Dendrimers are synthetic, high branched polymers with a number of functional groups that could bind to different macromolecules like drugs, oligosaccharides that makes it appropriate for target drug delivery. Today, some type of dendrimers like Jeffamines are developed possessing self antimicrobial activity. Hypothesis: we propose that combination of ethambutol with 3rd generation of Jeffamine core based dendrimer (P3) and mannose could both create a complex compound with high potency against mycobacteriumspecies that is targeted to macrophages via interaction between lectin receptors on immune cells and mannose molecules on outer branch of P3.


Key words: Tuberculosis, dendrimers, Jeffamines, Mycobacterium, ethambutol.