Abstract

Tuberculosis is the second lethal infectious disease caused by Mycobacterium species. This pathogens could cause severe disease like tuberculosis and leprosy in human. Today there are a number of anti tuberculosis agents utilized in treatment of this disease but multiple drug resistance is one of the major problems that end to failure in treatment. Dendrimers are synthetic, high branched polymers with a number of functional groups that could bind to different macromolecules like drugs, oligosaccharides that makes it appropriate for target drug delivery. Today, some type of dendrimers like Jeffamines are developed possessing self antimicrobial activity. Hypothesis: we propose that combination of ethambutol with 3^rd generation of Jeffamine core based dendrimer (P3) and mannose could both create a complex compound with high potency against mycobacteriumspecies that is targeted to macrophages via interaction between lectin receptors on immune cells and mannose molecules on outer branch of P3.

Key words: Tuberculosis, dendrimers, Jeffamines, Mycobacterium, ethambutol.