Abstract

 In this study, 16 benzimidazole and indole derivatives were synthesized and tested for in vitro antimicrobial activity by tube dilution and disc diffusion susceptibility test methods. The in vitro antimicrobial activity of the compounds was carried out by determining minimum inhibitory concentration value against various Gram-positive, Gram-negative bacteria and candida species fungi. The most active compound was 4-(5-methyl-3-phenyl-1H-indole) phenol (Compound 15) as shown by most inhibitory effect on Candida albicans, Candida glabrata, Staphylococcus aureus and Bacillus subtilis. Compound 15 showed better activity against yeast and Gram-positive bacteria than Gram-negative bacteria.

Key words: Benzimidazole, indole, minimum inhibitory concentration, antimicrobial activity.