African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5211

Full Length Research Paper

Synthesis and antimicrobial activity evaluation of some benzimidazole and indole derivatives

Didem Yuksek1, Oztekin Algul2*, Aylin Dögen1, Ozden Tari2, Emrah Kucuk2, Z. Feza Otag3, M. Sami Serin1
1Mersin University Faculty of Pharmacy Department of Pharmaceutical Microbiology, Mersin-Turkey. 2Mersin University Faculty of Pharmacy Department of Pharmaceutical Chemistry, Mersin, Turkey. 3Mersin University Faculty of Medicine Department of Medical Microbiology, Mersin, Turkey.
Email: [email protected]

  •  Accepted: 19 April 2013
  •  Published: 23 April 2013


 In this study, 16 benzimidazole and indole derivatives were synthesized and tested for in vitro antimicrobial activity by tube dilution and disc diffusion susceptibility test methods. The in vitro antimicrobial activity of the compounds was carried out by determining minimum inhibitory concentration value against various Gram-positive, Gram-negative bacteria and candida species fungi. The most active compound was 4-(5-methyl-3-phenyl-1H-indole) phenol (Compound 15) as shown by most inhibitory effect on Candida albicansCandida glabrataStaphylococcus aureus and Bacillus subtilis. Compound 15 showed better activity against yeast and Gram-positive bacteria than Gram-negative bacteria.


Key words: Benzimidazole, indole, minimum inhibitory concentration, antimicrobial activity.