African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5211

Full Length Research Paper

Antimicrobial, antioxidant activities and cytotoxicity evaluation of Artocarpus nigrifolius C. Y. Wu from Vietnam

Tran Minh Hoi1*, Pham Van The1, Do Ngoc Dai1, Nguyen Thanh Tra2, Ba Thi Cham2, Le Thi Tu Anh2, Nguyen Van Tuyen2, Tran Dinh Thang3 and Isiaka Ajani Ogunwande4
1Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam. 2Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam. 3Department of Food Technology, Vinh University, 182 Le Duan, Vinh City, Nghe An Province, Vietnam. 4Natural Products Research Unit, Department of Chemistry, Faculty of Science, Lagos State University, Badagry Express way Ojo, P. M. B. 0001, LASU Post Office, Ojo, Lagos, Nigeria.
Email: [email protected]

  •  Accepted: 14 October 2012
  •  Published: 09 April 2013


The extracts of leaf, stem bark, twigs and root of Artocarpus nigrifolius C. Y. Wu exhibited antibiotic activity against Bacillus subtilis, Staphylococcus aureus, Lactobacillus fermentum with the minimum inhibitory concentration value (IC50) of 3.65, 5.49 and 4.25 µg/ml, respectively; but not with Escherichia coli, Pseudomonas aeruginosa and Candida albicans. The extract from stem bark shows a higher anti-oxidant activity (EC50; 42.08 µg/ml) against DPPH than those of other extracts. Furthermore, the twig extract displayed significant cytotoxic activities against HepG2 and KB cell lines with IC50 value of 10.06 and 19.21 µg/ml, respectively, in comparison with others. The leaves and stem bark exhibited moderate cytotoxic activities to KB (IC50; 24.20 and 21.03 µg/ml, respectively) and MCF7 (IC50; 22.68 and 21.10 µg/ml, respectively).
Key words: Artocarpus nigrifolius, Moraceae, antimicrobial activity, antioxidant activity, cytotoxicity, Vietnam.