African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5210

Full Length Research Paper

Mycobacterium tuberculosis TLR2 agonists LprA, LM and Man-LAM induce notch1 and socs3 transcription

Erika Nahomy Marino-Marmolejo1, Citlalli Tornez-Benítez2, Vania Elvira Bonifaz-Peña3,Mabel Guzmán-Rodríguez3, Hugo Enrique López-González1, Abel Gutiérrez-Ortega1, Leticia Santos3* and Mario Alberto Flores-Valdez1*
1Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco, A.C., Guadalajara, Jalisco, 44270 México. 2Laboratorio Estatal de Salud Pública de Guerrero “Galo Soberón y Parra”, Acapulco, Guerrero, México, 39715. 3División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, A.C. San Luis Potosí, San Luis Potosí, 78216 México.
Email: [email protected], [email protected]

  •  Accepted: 20 July 2011
  •  Published: 04 August 2011


Mycobacterium tuberculosis employs a number of strategies to subvert host signaling events, leading to its persistence within macrophages. Upon infection, Mycobacterium bovis BCG induce the expression of suppressor of cytokine signaling 3 (socs3), in a Toll-like receptor 2 (TLR2)-Notch1-dependent manner. Purified phosphatidyl inositol di-mannosides (a TLR2 agonist) act as an inducer for the Notch1-socs3 pathway. This prompted us to analyze other TLR2 agonists seeking for additional molecules that may affect this pathway. We found that lipoprotein LprA, as well as glycolipids lipomannan (LM), and mannose-capped lipoarabinomannan (ManLAM) treatment of murine macrophages resulted in stimulation of notch1 and socs3 transcription.


Key words: Mycobacterium tuberculosis, Toll-like receptor 2 (TLR2), notch1, socs3, innate immunity.