African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5210

Full Length Research Paper

Antibacterial and cytotoxic activity of Eremurus persicus (Jaub and Spach) Boiss

Mojdeh Hakemi Vala1, Jinous Asgarpanah2*, Mohammad Hossein Hedayati3, Jeilan Shirali2 and Fatemeh Bagheri Bejestani4
1Microbiology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2Pharmacognosy Department, Pharmaceutical Sciences Branch and Pharmaceutical Sciences Research Center, Islamic Azad University (IAU), Tehran, Iran. 3Pasteur Institute of Iran (Karaj branch), Iran. 4Microbiology Department, Pharmaceutical Sciences Branch, Islamic Azad University (IAU), Tehran, Iran.  
Email: [email protected]

  •  Accepted: 30 May 2011
  •  Published: 18 August 2011

Abstract

Traditional medicine has a key role in health care worldwide. Obtaining scientific information about the efficacy and safety of the plants is one of the researcher's goals. In this research, the flowering aerial parts of Eremurus persicus were collected from Golpayegan (Isfahan, Iran) in May 2010. The extract was tested for its antibacterial activity against 4 Gram-positive bacteria strains (Staphylococcus aureus, Staphylococcus epidermidis and Bacillus cereus, Streptococcus pyogenes) and 5 Gram-negative bacterial strains (Escherichia coliSalmonella typhi, Shigella dysantriae, Klebsiella pneumoniae, Pseudomonas aeruginosa). Its cytotoxic activity was also investigated using MTT assay. Here we reported the antibacterial activity of E. persicus against S. aureus (MIC = 125 mg/ml), B. cereus (MIC = 15.62 mg/ml), E. coli (MIC = 125 mg/ml), S. typhi (MIC = 31.25 mg/ml), S. dysantriae (MIC = 0.48 mg/ml) for the first time. Furthermore the cytotoxic potentials of E. persicus on two cell lines, HeLa and Caco-2, were studied.

 

Key words: Eremurus persicus, antibacterial activity, cytotoxic activity.