African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

Distribution of sulfamethoxazole trimethoprim constin in Vibrio cholerae isolated from patients and environment in Iran

Maryam Adabi1,2, Mosadegh Jabbari3 and Abdolaziz Rastegar Lari1*
1Anti-microbial Resistant Research Center. Tehran University of Medical Science, Tehran, Iran. 2Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran. 3 Rasool-E-Akram hospital, Tehran University of Medical Sciences, Tehran Iran.
Email: [email protected]

  •  Accepted: 30 May 2011
  •  Published: 30 September 2011

Abstract

The  occurrence  of  drug-resistant  Vibrio  cholerae  is  being  reported  with  increasing  frequency  worldwide. Spread of resistant strains has been attributed, in part, sulfamethoxazole trimethoprim-constin (SXT-C). Sixty V. cholerae isolates obtained from cholera patients from different provinces in Iran during 2004 to 2006 and thirty-seven V. cholerae strains from surface water sources at 5  different locations in Tehran, Iran during 2006 were subjected to antibiotic susceptibility  testing and polymerase chain reaction amplification of SXT-CIn clinical isolates the highest and the least levels of antibiotic resistance were seen to SXT, streptomycin and chloramphenicol (95, 95 and 92%, respectively) and doxycycline, gentamicin and oxytetracycline (0, 3 and 3%, respectively). PCR for SXT element of clinical and environmental isolates was positive for 95 and 19% of isolates, respectively. The results of this study showed that among the clinical and environmental V. cholerae resistance to SXT, streptomycin and chloramphenicol could be, in part, due to wide distribution of SXT-C isolates.

 

Key words: Anti-microbial resistant, Vibrio cholerae, sulfamethoxazole trimethoprim-constin (SXT-C).