African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5210

Full Length Research Paper

Survey of extensively drug-resistant tuberculosis XDR-TB) in Iran-Tehran: A retrospective study

Hadizadeh Tasbiti A. R.1, Yari SH1*, Karimi A.1, Fateh A.1, Bahrmand A.1,2, Saifi M.1, Jabarzadeh E.1, Masomi M.1, Noor Nematolahi A.1, Khanipoor S.1, Ebrahimzadeh N.1,Ghazanfari M.1, Sakhaii F.1, Blori F.1, Balmeh H.1, Vahidi E.1, Abdolrahimi F.1 and Poorazar Sh.1
  1Department of Mycobacteriology, Pasteur Institute of Iran, Pasteur Ave 13164, Tehran-Iran. 2Department of Molecular Pathology, Methodist Hospital, Houston, Texas 77030, USA.
Email: [email protected]

  •  Accepted: 09 September 2011
  •  Published: 16 October 2011



The emergence and spread of multidrug resistant (MDR) and extensively drug-resistant tuberculosis (XDR) has raised public health concern about global control of TB. Our objective was to estimate the incidence of XDR-TB as compared to susceptible controls from TB patients in Tehran-Iran between 2006 and 2009.Sputum culture and drug susceptibility testing (DST) was done for patients with known or suspected TB. The strains that were identified as MDR were subjected to susceptibility testing for second-line drugs. Of 1126 culture-positive cases with first line drug susceptibility test, 91(8.08%) were Non-tuberculosis (Atypical) isolates, 8(0.7%) M. bovis and 1027(91.2%) M. tuberculosis. We detected MDR-TB in 26 patients (2.5%), of whom 2(7.7%) had XDR-TB. One of the XDR-TB patients with positive HIV infection died. This study cannot give an indication of XDR-TB rates in Iran. However, the results of this study document the existence of XDR-TB in Iran and indicate a need for surveillance data to define the magnitude and trends of this serious, contagious disease.


Key words: Multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant (XDR-TB), tuberculosis.