African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5211

Full Length Research Paper

Activity of ethanolic extracts of Asparagopsis taxiformis against the major molecular types of Cryptococcus neoformans/C. gattii complex

Giuseppa Genovese, Orazio Romeo, Marina Morabito*, Domenico Alessi, Giuseppe Criseo and Caterina Faggio
Department of Biological and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres, 31, 98166 Messina, Italy.
Email: [email protected]

  •  Accepted: 26 April 2013
  •  Published: 21 May 2013


Infections due to Cryptococcus neoformans/C. gattii complex have been reported to afflict, not only humans but also other mammals including seabirds and cetaceans, proving that the actual animal exposure to these fungi in nature could be underestimated. In this study, antifungal activity of ethanolic extracts obtained from red alga Asparagopsis taxiformis was evaluated against eight major genotypes of the C. neoformans/C. gattiicomplex, using both disk diffusion and microdilution broth methods. The algal extracts were active against all fungal strains tested and were not cytotoxic to human red blood cells. This study suggests that Asparagopsis taxiformis extracts possess attractive antifungal properties which should encourage the search for new drugs derived from marine algae.


Key words: Cryptococcosis, Cryptococcus neoformansCryptococcus gattii,Asparagopsis, seaweeds, red algae, crude extracts, antifungal.