African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

Neurophysiological and behavioral effects of mycotoxin deoxynivalenol and fumonisin

Mansour Attia Al-Hazmi1* and Abeer M Waggas2
1Faculty of Sciences and Arts, Khulais, King Abdulaziz University, Jeddah, Saudi Arabia. 2Department of Biology (Zoology), Sciences Faculty for Girls, King Abdulaziz University, Jeddah, Saudi Arabia.  
Email: [email protected]

  •  Accepted: 27 November 2012
  •  Published: 09 April 2013

Abstract

Two experiments were conducted to compare the effects of feeding blends of wheat grains naturally contaminated with deoxynivalenol (DON) and maize products contaminated with Fusarium (FUM) mycotoxins on brain regional concentration of  brain dopamine (DA), norepinephrine (NE) and serotonin (5-HT)  in hippocampus, mid brain, cortex, striatum, pons and medulla and cerebellum of male albino mice. Daily feeding of wheat or maize grains contaminated with deoxynivalenol  in a dose level (803 µg/kg) or  fumonisin  in a dose level (1330 ppb)  for six weeks caused highly significant  increase in dopamine (DA), norepinephrine (NE) and serotonin (5-HT ) contents, in most of the studied mice brain areas. When all the studied brain areas were compared, it can be concluded that hypothalamus-dopamine concentration was more sensitive towards the studied toxicants. On the other hand, except for norepinephrine in pons and medulla oblongata, there was a significant increase in epinipherine and serotonin levels at all the studied brain areas.  Maximal concentration, however, was attained in the cortex for both neurotransmitters. Additionally, rearing behavior was found to increase following feed intake of the test feed and deoxynivalenol was found to modulate more behavioral disturbances as compared with fuminisin.  The data recorded also showed a highly significant increase in the aggressive and locomotor behavior of the intoxicated albino mice.

 

Key words: Deoxynivalenol, fumonisin, brain areas, monoamines.