In order to determine whether infection with Helicobacter pylori and CagA strain is associated with hyperemesis gravidarum (HG), a study was conducted in Al- Zahra obstetrics and gynecology hospital in Tabriz, Iran between May 2007 and February 2008. Forty-four (44) pregnant women with the diagnosis of HG and forty-four (44) normal pregnant women of matched gestational age were included in this prospective study. Serum H. pyloriimmunoglobulin G antibody titer and CagAantibodies were measured for both groups of women. There was no difference in seropositivity of H. pylori antibody between subjects with hyperemesis when compared with controls. The prevalence of H. pylori infection with CagA + gene was significantly higher among control group when compared with study group. HG seems not to be associated with H. pylori infection. The results of this study suggested higher levels of CagA H. pylori infection in control groups.
Key words: Helicobacter pylori, hyperemesis gravidarum, CagA + gene.
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