African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5238

Full Length Research Paper

Elevated levels of serum IL-32 in patients with active pulmonary tuberculosis

Fukai Bao1, Xia Wen1, Aihua Liu2*, Xulei Dai1 , Qin Zhao3, Yaling Wang3, and Songqin Lu3
1Department of Microbiology and Immunology, Kunming Medical University, Kunming 650031, China. 2Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming 650031, China. 3The Third Hospital of Kunming, Kunming 650041, China.
Email: [email protected]

  •  Accepted: 22 November 2012
  •  Published: 27 November 2012

Abstract

To explore interleukin-32 relationship with tuberculosis, we detected interleukin-32 expression level in the serum samples of patients with active tuberculosis. Forty (40) TB patients (16 males and 24 females) from Third People's Hospital of Kunming, China, and 17 healthy controls (10 males and 7 females) from the Center for Disease Control and Prevention of Kunming, China, were selected. An enzyme-linked immunosorbent assay (ELISA) was used to quantify IL-32 levels. IL-32 levels of TB group were significantly higher than the control group (p<0.001). These data show that IL-32 plays an important role in immune responses to human infection with Mycobacterium tuberculosis.

 

Key words: Interleukin-32, Mycobacterium tuberculosis, tuberculosis, enzyme-linked immunosorbent assay.