African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

Antimicrobial activity of aqueous extracts of sea cucumber (Isostichopus badionotus) from the coast of Yucatan, Mexico

  Fernando Moguel-Salazar1,2*, Elizabeth Ortiz-Vázquez2, Rossanna Rodríguez-Canul1and Leticia Olivera-Castillo1
  1Laboratorio de Inmunología y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Unidad Mérida, Km. 6 Antigua Carretera a Progreso, CORDEMEX. Mérida, Yucatán, 97310 México. 2Laboratorio de Microbiología Aplicada y Molecular, Instituto Tecnológico de Mérida Av.Tecnológico km. 4.5 S/N C.P. 97118, Mérida, Yucatán.
Email: [email protected]

  •  Accepted: 05 July 2013
  •  Published: 12 July 2013



The antibacterial activity of aqueous extracts from different tissues of Isostichopus badionotus was evaluated in this study. The antibacterial activity was detected in aqueous extracts of muscle and respiratory tract. A high antibacterial activity was found in the Membrane Protein fraction (MP) muscle on Staphylococcus aureusVibrio cholerae,Escherichia coli and Pseudomonas aeruginosa. The minimum inhibitory concentration (MIC) of MP against S. aureus was 37.4 and 8.4 μg/ml protein for V. cholerae. It also showed resistance to treatment with proteinase K and heat, indicating that the active compound of this fraction is from non-protein origin. The results of this study suggest thatI. badionotus is a potential source for discovering new antibiotics.


Key words: Isostichopus badionotus, aqueous extracts, antimicrobial activity, sea cucumber, SaureusVcholerae.