Abstract

Absolute alcohol, stress, pyloric ligation and others are well-rounded experimental gastric ulcer models widely used to evaluate the anti-ulcer activity of drugs (Wang et al., 2007; Zhang et al., 2007; Huang et al., 2004; Oyagi et al., 2010). In the model evaluation process, ulcer index is a more important indicator. So in this experiment, the absolute alcohol gastric ulcer model is taken as an example to discuss a model of gastric ulcer index, which can be used as a new method to calculate the reduction of the systematic errors that exist in the experiment. The oral ethanol approach was used to establish an absolute alcohol gastric ulcer model, and impose certain medication, while traditional methods and the establishment of grayscale image analysis methods were used for calculating its ulcer index respectively, before comparing the differences between the two methods. Grayscale image analysis methods and traditional methods have significant correlation (r = 0.819, P＜0.01) and similarity (r = 0.951). A grayscale image analysis method not only proves to be a more scientific approach to measure rat gastric ulcer area, but also provide a new method to evaluate drug efficacy to some extent.

Key words: Gastric ulcer, ulcer index, gray-scale image analysis, image J.