African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5211

Full Length Research Paper

Analysis of codon usage in peste des petits ruminant’s virus

Xin-sheng Liu, Yong-lu Wang*, Yong-guang Zhang, Yu-zhen Fang, Li Pan, Jian-liang LÜ, Peng Zhou, Zhong-wang Zhang, Shou-tian Jiang
State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Email: [email protected]

  •  Accepted: 08 September 2011
  •  Published: 16 November 2011



In this study, it is indicated that the bias of synonymous codon usage of Peste des Petits Ruminants virus (PPRV) gene is lower without intra-specific performance through analysis on PPRV gene synonymous codon usage. The virus has interspecies codon usage specific performance in Morbillivirus. PPRV synonymous codon usage pattern is mainly caused by genetic base, the changes of codon usage bias are mainly caused by pressure of gene mutations. Meanwhile, the gene function also determines PPRV codon usage to some extent. However, the gene length and translation stress have no influence on codon usage patterns in genes of the virus. The codon usage bias pattern of PPRV that we analyzed plays an important role for understanding the evolution process of the virus, in particular to understanding the role of mutation and selection in this process.


Key words: Peste des petits ruminants virus, synonymous codon usage, mutational bias, base composition.