African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5210

Full Length Research Paper

Evaluation of GB virus C (GBV-C)/hepatitis G virus (HGV) and hepatitis type B viruses (HBV) infections in patients with non-Hodgkin’s lymphoma

  Alireza Khodavandi1Ù­, Ramin Yaghobi2, Fahimeh Alizadeh3, Mitra Mirzaee2, Mahdi Roshan Nia4 and Mani Ramzi5
  1Department of Paramedical Sciences, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran. 2Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 3Department of Paramedical Sciences, Yasuj Branch, Islamic Azad University, Yasuj, Iran. 4Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 5Hematology Research Center and Bone Marrow Transplant Unite, Shiraz University of Medical Sciences, Shiraz, Iran.       
Email: [email protected], [email protected]

  •  Accepted: 30 July 2011
  •  Published: 30 October 2011



GB virus C (GBV-C)/hepatitis G virus (HGV) by infecting and encourage proliferative process of the mononuclear cells, may implicate in lymphomagenesis including non-Hodgkin’s lymphoma (NHL). Therefore, in this study the prevalence of GBV-C/HGV and HBV infections were evaluated in patients with NHL and controls. In a cross sectional study, blood samples were collected from 70 patients with NHL and 100 healthy controls. The infective markers of GBV-C/HGV and HBV viruses were evaluated in both studied groups by enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) protocols, respectively. Anti-E2-Ab was detected in 1.4 of 70(1%) of NHL patients who has not the history of HBV infections. HGV-RNA was diagnosed in 2 of 70 (2.9%) of NHL patients and one of them was also shown the history of HBV infection. HGV-RNA was diagnosed in 1of 100 (1%) of controls but none of them was shown seroconversion to GBV-C/ HGV. HBV-DNA was found in 8 of 70 (11.6%) of NHL patients and 2 of 100 (2%) of controls. Significant differences were found in the prevalence of: HBV-DNA (P=0.013), HBsAb (P=0.001), and HBc-IgG-Ab (P=0.002) between NHL and controls. Determination of active and persistent infections of GBV-C/ HGV with or without HBV infection in NHL patients compared with control population proposed an association between viral hepatitis infections and NHL.


Key words: Non-Hodgkin’s lymphoma (NHL), GB virus C (GBV-C), hepatitis G virus (HGV).