African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5211

Full Length Research Paper

Pathogens change in spontaneous bacterial peritonitis patients with cirrhosis

  Yanzi Gou1*, Fangxin Zhang1, Zhenbin Liang2, Xuefan Bai3, Lei Pan3, Wei Wang1, Bo Liu3, Jiuping Wang3 and Dingcheng Wang4
  1Department of Gastroenterology, Lan Zhou General Hospital of People Liberation Army, Lanzhou,730050, China. 2Surgery,68302 Military Hospital, Shaanxi,710000,China. 3Centre of Diagnosis and Treatment for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China. 4Clinical Laboratory Department, Tangdu Hospital, the Fourth Military Medical University Xi’an 710038,China.
Email: [email protected]

  •  Accepted: 23 September 2010
  •  Published: 04 January 2011



The aim of this study was to determine the distribution of clinical microorganisms isolated from spontaneous bacterial peritonitis patients. Ascitic fluid was collected from these patients and cultured for pathogens. The patients were placed into three groups, Group A (01/1996 to 12/2000), B (01/2001 to 12/2005) and C (01/2006 to 06/2010) and the clinical data were compared among these groups. There was a significant difference in the ratio of pathogens (Gram-positive bacteria/ isolated pathogens, Gram-negative bacteria/ isolated pathogens) between groups A and C (P < 0.001). Spontaneous bacterial peritonitis patients with Gram-positive bacteria used significantly more antibiotics within 30 days compared to those with Gram-negative bacteria (P < 0.001). In recent years, the types of isolated pathogens have significantly changed in Northern China. Such changes have also been observed in other countries and have been attributed to long-term antibiotic therapy and invasive procedures. Changes in the epidemiology of pathogens that cause spontaneous bacterial peritonitis must be monitored for optimal treatment.


Key words: Pathogens, gram-positive bacteria, spontaneous bacterial peritonitis, cirrhotic patients