African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

Quantitative changes of serum immunoglobulins A, G and M among patients with Hepatitis A

Vatev N1, Stoycheva M2*, Petrov A2 and Terzieva T3
  1Department of Hygiene, Ecology and Epidemiology, Medical University – Plovdiv, Bulgaria. 2Department of Infectious Diseases, Parasitology and Tropical Medicine, 4002 Bul. Vasil Aprilov 15A, Medical University – Plovdiv, Bulgaria. 3Department of Central University Clinic Laboratory, Medical University – Plovdiv, Bulgaria.
Email: [email protected]

  •  Accepted: 10 October 2011
  •  Published: 23 November 2011



There is evidence of change in the level of serum immunoglobulins (Ig) in patients with hepatitis A and attempts for these changes to be associated with the clinical course of the disease. The aim of this study is to establish the quantitative changes of IgA, IgG and IgM in hepatitis A patients and to evaluate their significance for the clinical course of the disease. A total of 125 persons were examined: 35 patients with prolonged form of HAV; 51 patients with self limited form of HAV; 35 healthy persons – control group. In comparison with the control group, a substantial increase of IgA, IgG and IgM was found in patients with prolonged form of HAV. In patients with self limited form of HAV, the increase was significant for IgG and IgA, and insignificant for IgM. The research on serum Igsupplements the research panel performed for patients with HAV and may have prognostic importance in determining the severity of the disease and the prolonged forms of HAV.


Key words: Hepatitis A, serum immunoglobulins, quantitative changes.