African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

Evaluation of immunogenic properties of monovalent and polyvalent inactivated bovine virus diarrhea virus (BVDV) vaccines

Vladimir S. Kurcubic1*, Nenad S. Milic2, Radojica D. Djokovic1 and Zoran Z. Ilic3  
1Department of Animal Science, Faculty of Agronomy, Cacak, Cara Dusana 34, 32.000 Cacak, University of Kragujevac, Serbia. 2Department of Microbiology, Faculty of Veterinary Medicine, University of Belgrade, Bulevar oslobodjenja 18, 11.000 Belgrade, Serbia. 3Department of Animal Science, Faculty of Agriculture, University of Prishtina -Zubin Potok, Jelene Anzujske bb, Serbia.
Email: [email protected]

  •  Accepted: 23 June 2011
  •  Published: 09 September 2011


This study is aimed at evaluating the immunogenicity of two inactivated (mono- and polyvalent) vaccines containing bovine virus diarrhea virus (BVDV) reference and field strains. Three experimental groups were formed: 10 calves vaccinated twice (days 1 and 28) subcutaneously (s/c) with 2 ml of inactivated polyvalent vaccine per animal (Group 1); 10 calves vaccinated twice (days 1 and 28) subcutaneously (s/c) with 2 ml of inactivated monovalent vaccine per animal (Group 2) and 9 unvaccinated calves (Control, Group C). Blood sera were obtained from immunized animals (standard procedure: on days 0, 14, 28, 42 and 56 post-immunization). Geometric mean titer (GMT) values for BVDV neutralizing antibodies were substantially higher in blood sera of calves receiving the inactivated monovalent vaccine. The immune response developed more rapidly in calves immunized with the monovalent vaccine.


Key words: Bovine virus diarrhea virus, immunogenic properties, inactivated vaccines.