The aim of this study was to screen the presence of antimicrobial activities in the marine mollusc Thais tissoti and Babylonia spirata. In this study, the human bacterial pathogen Klebsiella pneumonia (10.02 ± 0.11 mm) and fungal pathogen Aspergillus niger (12.09 ± 0.06 mm) showed most sensitive to ethyl acetate extracts of T. tissoti. In B. spirata extracts, bacterial pathogen Proteus mirabilis (7.02 ± 0.04 mm) and fungal pathogen Candida albicans (8.13 ± 0.15* mm) exhibit high zone of inhibition against n-butanol extracts. Among the fish bacterial pathogens assayed, Aeromonas hydrophila (9.22 ± 0.03* mm) and fungal pathogen Ichthyophonus sp. (5.21 ± 0.11 mm) showed more sensitivity to n- butanol extract of T. tissoti. In B. spirata extracts, bacterial pathogen A. hydrophila (11.2 ± 0.6* mm) and fungal pathogens A. niger (15.12 ± 0.23* mm) showed most sensitive to n-butanol extracts. From biofilm bacteria, Micrococcus luteus (7.02 ± 0.11* mm), Micrococcus sp. (7.25 ± 0.03* mm) showed high sensitivity to n-butanol extracts of molluscs T. tissoti and B. spirata. These results signify that the marine mollusc extracts express remarkable antimicrobial activity against isolated microbes. The result strongly suggests that the molluscs extracts can be used as antimicrobial agents and further studies for purification and structural elucidation of antimicrobial drugs.
Key words: Antibacterial, antifungal, human pathogen, fish pathogen, biofilm, marine mollusks.
