African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5211

Full Length Research Paper

Chemical constituents from the fungus Ganoderma tropicum (Jungh.) Bres. and their cytotoxic activities

Qing-yun Ma1#, Li-li Hu1#, Ling-mei Kong2, Sheng-zhuo Huang1, Hao-fu Dai1, Yan LI2* and You-xing Zhao1*
1Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. 2State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
Email: [email protected], [email protected]

  •  Accepted: 29 March 2013
  •  Published: 16 April 2013


 The chemical investigation on the fruiting bodies of white rot fungus Ganoderma tropicum(Jungh.) Bres. led to the isolation of ten natural compounds by column chromatography on silica gel and sephadex LH-20. Their structures were elucidated by nuclear magnetic resonance (NMR) analysis as well as comparison with those reported in the literatures. Compounds 1-10 were isolated for the first time from this fungus. The bioassay of cytotoxic activities of seven compounds was evaluated against five human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7 and SW-480. Compound jacareubin (1) displayed obvious cytotoxic activities on HL-60, SMMC-7721, A-549, MCF-7 and SW-480 with IC50values of 7.49, 9.04, 4.44, 21.61 and 14.02 μmol.L-1, respectively. Compound 22E-7α-methoxy-5α,6α-epoxyergosta-8(14),22-dien-3β-ol (9) also exhibited definite cytotoxic activities on HL-60, MCF-7 and SW-480. The discovery of cytotoxic compounds exhibited potential effect on anti-tumor of G. tropicum.


Key words: Ganoderma tropicum, chemical constituents, cytotoxic activities.