Abstract

There is considerable interest in alternative/adjuvant approaches for the eradication of infections using biologically active compounds, especially antioxidants from plants. Phenolic compounds in grape products play important roles for antioxidant, anti-inflammatory, and antimicrobial effects. Grapes are rich sources of potentially bioactive polyphenols. This study was conducted to measure the antibacterial activity of ethanol extract of total grape (Vitis vinifera L., Vitaceae) against several pathogenic bacteria.Grape was extracted by percolation method. Aliquots of the extracts at variableconcentrations were then incubated with different bacterial strains, and the antimicrobialactivities of the ethanolic extracts from total grapes were determined by the minimum inhibitory concentration (MIC). Total grapes extract inhibited significantly, the growth of the tested bacterial strains. Among the bacterial strains tested, Staphylococcus aureus was the most susceptibleility. Results from these findings suggest that total grapes extract may be used as natural antibacterial for treatment of some diseases, especially local skin diseases.

Key words: Antimicrobial activity, grape, minimum inhibitory concentrations (MIC).