African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5211

Full Length Research Paper

Antibiotic resistance pattern of Pseudomonas aeruginosa isolated from patients of lower respiratory tract infection

Piyush Tripathi1, Gopa Banerjee1*, Shivani Saxena1, Mahendra Kumar Gupta1, and P. W. Ramteke2
1Department of Microbiology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, (U.P.) 226003, India. 2Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad, India.
Email: [email protected]

  •  Accepted: 22 August 2011
  •  Published: 23 September 2011


The aim of this study was to determine the antibiotic susceptibility pattern of Pseudomonas aeruginosa from sputum samples of lower respiratory tract infection (LRTI) patients admitted to the Department of Pediatrics and Pulmonary Medicine and also to update clinicians on various antimicrobial alternatives available in treatments. Sputum samples from 298 patients were cultured identified and antibiotic sensitivity was performed by standard methods. Out of the 298 sputum samples from LRTI patients 102 (34.23%) patients had established P. aeruginosa aetiology. Cefepime and ceftazidime show more resistance to P. aeruginosa isolates with resistance 36.27 and 35.30%, respectively. Least resistance was noted for piperacillin/tazobactam and Imipenam that is, 4.90 and 5.88%, respectively. Fifty percent P. aeruginosa are intermediate or marginally sensitive to gentamycin. Piperacillin/Tazobactam and Imipenam was found to be the most sensitive drug against P. aeruginosa in LRTI patients. Gentamycin resistance is continuously increasing.
Key words: Antibiotic susceptibility profile of P. aeruginosa, lower respiratory tract infection, multiple antibiotic resistance.