Abstract

Considering various effects of mucoadhesive suspension containing Ciprofloxacin, it was found that newly designed mucoadhesive formulation was better than its conventional immediate release preparation. Due to that their in vitro antibacterial activity was also studied and compared. It was found that the newly designed mucoadhesive formulation showed much larger zones of inhibition against all the strains used in the study than the conventional immediate release preparation. In addition, this novel formulation and even the standard discs of Ciprofloxacin produced more or less similar zones of inhibition. However, the conventional immediate release preparation was much inferior to the standard discs as far as the zones of inhibition were concerned.

Key words: Ciprofloxacin, mucoadhesive formulation, conventional immediate release preparation, antibacterial activity.