African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5210

Full Length Research Paper

Antibacterial activity study of a mucoadhesive suspension containing ciprofloxacin

Subhashree Sahoo1*, Chandra Kanti Chakraborti1 and Subash Chandra Mishra2
  1Kanak Manjari Institute of Pharmaceutical Sciences, Chhend, Rourkela-769015 Orissa, India. 2Department of Metallurgical and Materials Engineering, National Institute of Technology, Rourkela- 769008, Orissa, India.
Email: [email protected]

  •  Accepted: 01 February 2011
  •  Published: 04 March 2011



Considering various effects of mucoadhesive suspension containing Ciprofloxacin, it was found that newly designed mucoadhesive formulation was better than its conventional immediate release preparation. Due to that their in vitro antibacterial activity was also studied and compared. It was found that the newly designed mucoadhesive formulation showed much larger zones of inhibition against all the strains used in the study than the conventional immediate release preparation. In addition, this novel formulation and even the standard discs of Ciprofloxacin produced more or less similar zones of inhibition. However, the conventional immediate release preparation was much inferior to the standard discs as far as the zones of inhibition were concerned.


Key words: Ciprofloxacin, mucoadhesive formulation, conventional immediate release preparation, antibacterial activity.