African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 363

Article in Press

Synthesis of N-alkyl-3- (1H-benzimidazolyl) -2-chloroquinoline derivatives potential candidates against infectious organisms

Gbe Gondo Didier DIOMANDE1, Sagne Jacques AKPA1, Doumade ZON2 et Ané ADJOU1

  •  Received: 02 December 2020
  •  Accepted: 22 April 2021
In the search for new drugs possessing the activities we have sought to synthesize new quinoline derivatives which constitute a basic heterocyclic support of some drugs such as quinine, chloroquine marketed under the name Nivaquine®, Mefloquine®, used in the treatment of malaria. The objective of this work is to contribute to the synthesis of new derivatives of quinoline. It consists in introducing heterocycles such as benzimidazole in its 3-position. The introduction of heterocyclics, aryls or alkyls on the pyrrolic nitrogen of benzimidazole, allowed us to obtain compounds 3a-f. The chemical structures of all these compounds were determined by NMR (1H, 13C) and electron impact mass spectrometry.

Keywords: Quinoline, benzimidazole, aryls, alkyls