African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2296

Full Length Research Paper

Chemical composition and antimicrobial activity of essential oil from Brazilian plants Acanthospermum australe, Calea fruticosa and Mikania glauca

Cintia Cristina de Carvalho
  • Cintia Cristina de Carvalho
  • Departamento de Química, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Campus Universitário Morro do Cruzeiro, Bauxita, CEP 35400-000, Ouro Preto, MG, Brazil.
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Izabel Cristina Casanova Turatti
  • Izabel Cristina Casanova Turatti
  • Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903, Ribeirão Preto-SP, Brazil.
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Norberto Peporine Lopes
  • Norberto Peporine Lopes
  • Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903, Ribeirão Preto-SP, Brazil.
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Marcos José Salvador
  • Marcos José Salvador
  • Departamento de Biologia Vegetal, Curso de Farmácia, BTPB, Instituto de Biologia, Universidade Estadual de Campinas-UNICAMP, 13083-970, Campinas, SP, Brazil
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Andréa Mendes do Nascimento*
  • Andréa Mendes do Nascimento*
  • Departamento de Química, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Campus Universitário Morro do Cruzeiro, Bauxita, CEP 35400-000, Ouro Preto, MG, Brazil.
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  •  Received: 28 November 2013
  •  Accepted: 28 March 2014
  •  Published: 15 April 2014

Abstract

The essential oils of leaves of Acanthospermum australe, Calea fruticosa and Mikania glauca (Asteraceae) from southeastern Brazil were obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS). Oxygenated sesquiterpenes were predominant in C. fruticosa (47.8%) whereas sesquiterpenes hydrocarbons constituents predominated in A. australe (85.1%) and M. glauca (63.3%) oils. Caryophyllene oxide, α-cadinol and selin-11-en-4-α-ol were the most abundant components in C. fruticosa. Germacrene D, (E)-caryophyllene and bicyclogermacrene were the major components observed in the essential oil obtained from the leaves of A. australe and M. glauca. The antimicrobial capacity of the oils was tested. The results showed that the oils have antimicrobial activity against Gram-negative bacteria and Candida glabrata, with minimal inhibitory concentration (MIC) values between 50 and 1000 µg/ml.

 

Key words: Asteraceae, essential oil, gas chromatography-mass spectrometry (GC-MS), antimicrobial activity, Brazilian flora.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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