African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2298

Full Length Research Paper

Maternal exposure to aqueous extract of Mentha pulegium L. inducing toxicity to embryo development in rats

Marli Gerenutti*
  • Marli Gerenutti*
  • Laboratory for the Development and Evaluation of Bioactive Substances, Laboratory for the Toxicological Research (Lapetox), University of Sorocaba (UNISO) , Cidade Universitária, Rod. Raposo Tavares km 91, CEP 18023-000 Sorocaba, São Paulo, Brasil.
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Lívia Modesto
  • Lívia Modesto
  • Laboratory for the Development and Evaluation of Bioactive Substances, Laboratory for the Toxicological Research (Lapetox), University of Sorocaba (UNISO) , Cidade Universitária, Rod. Raposo Tavares km 91, CEP 18023-000 Sorocaba, São Paulo, Brasil.
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Vanessa Alessandra Carrara
  • Vanessa Alessandra Carrara
  • Laboratory for the Development and Evaluation of Bioactive Substances, Laboratory for the Toxicological Research (Lapetox), University of Sorocaba (UNISO) , Cidade Universitária, Rod. Raposo Tavares km 91, CEP 18023-000 Sorocaba, São Paulo, Brasil.
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Stefani Alves Magalhães
  • Stefani Alves Magalhães
  • Laboratory for the Development and Evaluation of Bioactive Substances, Laboratory for the Toxicological Research (Lapetox), University of Sorocaba (UNISO) , Cidade Universitária, Rod. Raposo Tavares km 91, CEP 18023-000 Sorocaba, São Paulo, Brasil.
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Nobel Penteado de Freitas
  • Nobel Penteado de Freitas
  • Laboratory for the Development and Evaluation of Bioactive Substances, Laboratory for the Toxicological Research (Lapetox), University of Sorocaba (UNISO) , Cidade Universitária, Rod. Raposo Tavares km 91, CEP 18023-000 Sorocaba, São Paulo, Brasil.
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Magali Glauzer Silva
  • Magali Glauzer Silva
  • Laboratory for the Development and Evaluation of Bioactive Substances, Laboratory for the Toxicological Research (Lapetox), University of Sorocaba (UNISO) , Cidade Universitária, Rod. Raposo Tavares km 91, CEP 18023-000 Sorocaba, São Paulo, Brasil.
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  •  Received: 15 January 2014
  •  Accepted: 16 May 2014
  •  Published: 05 June 2014

Abstract

The aim of this study was to observe the effect of orally administrated aqueous extract of Mentha pulegium L. on female rats pregnancy and on the physical development of fetuses. It was administered daily doses of 1.0, 2.5 and 5.0 g per kg of body weight or alternates doses of 2.0 and 4.0 g/kg of the M. pulegium L. aqueous extract, to sixty pregnant rats from the 4th day to the 20th day of pregnancy. On the 21th day of pregnancy, the intact rat fetuses were isolated. The aqueous extract of M. pulegium L. induced several changes in the reproductive performance of female rats and significant alterations in the skeletal development of fetuses.

 

Key words: Mentha pulegium, medicinal plants, abortifacient agents, reproduction, teratology.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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