African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2296

Full Length Research Paper

Modulation of renal redox status by garlic based on route of administration in rat

Sonia Hamlaoui1*, #, Oumayma Samti1#, Meherzia Mokni1, 3, Nadia Limam1, Ferid Limam2, Ezzedine Aouani2, Mohamed Amri1 and Lamjed Marzouki1, 3
1Laboratoire de Neurophysiologie Fonctionnelle et Pathologies, Faculté des Sciences de Tunis, Campus Universitaire Manar II 2092 Tunis, Tunisie. 2Laboratoire des Substances Biologiquement Actives, Centre de Biotechnologie, Technopole Borj-Cedria, BP 901, 2050 Hammam-Lif, Tunis, Tunisie. 3Institut supérieur de biotechnologie de Béja, Avenue Habib Bourguiba – B.P. 382 – 9000 Béja, Université de Jendouba, Tunisie.
Email: [email protected]

  •  Accepted: 12 April 2012
  •  Published: 08 July 2012

Abstract

Several controversies persist about the beneficial or toxic effects of garlic. The present study was undertaken to determine the effects of high dosage garlic according to its mode of administration in rat. We studied the ability of high dosage garlic to modulate kidney antioxidant status when administered either orally (PO) or by intraperitoneal (IP) route. In renal tissue homogenate, PO garlic was antioxidant as it decreased malondialdehyde (MDA), protein carbonyl, free iron and hydrogen peroxide (H2O2) and increased antioxidant enzyme activities as peroxidase (POD) and superoxide dismutase (SOD). IP garlic was pro-oxidant as it increased protein carbonyl and H2O2, has no effect on MDA but unexpectedly increasedcatalase (CAT) activity and decreased POD and SOD activities. In plasma compartment, PO garlic has no effect on creatinine and urea levels whereas IP treatment increased them. High garlic dosage is safer when PO administered.

 

Key words: Garlic, kidney, redox status, administration mode, lipoperoxidation, protein carbonylation, free iron, hydrogen peroxide, antioxidants enzymes.