Abstract

Indomethacin is one of the old non-steroidal anti-inflammatory drugs and it inhibits cycloxygenase I and II. The objective of this research is to study the clinical and histopathological effect of indomethacin which is usually used in surgery as an analgesic drug and which is evaluated on the process of healing of surgical wound. We selected 15 New Zealand white rabbits with the same condition and after numbering, they were divided into three groups of 5 rabbit in each group. Then, in each group after anesthesia with xylazine and ketamine, a surgical wound was created in the right lateral region of mandible with biopsy punch and then, after 12 days, clinical and histopathological effects of drug evaluated in low dose and high dose groups when compared with control group that received placebo. It was evident that the use of this drug had positive effects on healing, and this was also obvious in clinical and histopathologic findings in both low dose and high dose groups when compared with control group. Also use of low dose of indomethacin had better effects on healing process after surgical trauma.

Key words: Indomethacin, healing, gum injuries, rabbit.