Abstract

Periprosthetic osteolysis is the most prevalent complication after total joint arthroplasty. It often results in aseptic loosening of the implant, which is required for revision surgery. Wear debris has been recognized as a key factor in the initiation and development of periprosthetic osteolysis, and yet there is no approved treatment available to it. Adiponectin is a hormone secreted by adipose tissue. Many researchers have reported that adiponectin can block osteoclastogenesis and promote osteoblast proliferation. We then hypothesize that adiponectin may play an efficient role in the therapy of periprosthetic osteolysis, which may offer new therapeutic options for the management of periprosthetic osteolysis after total joint arthroplasty.

Key words: Adiponectin, periprosthetic osteolysis, wear debris.