Abstract

To explore the risk factors and clinical significance of severe acute pancreatitis (SAP) complicated with acute cholecystitis (AC) in later stage. With case-control study method, collected clinical data of 42 cases of SAP complicated with AC patients (the experimental group) and 210 cases of SAP patients (the control group) from March, 2002 to March, 2011. Then used single factor non-conditional logistic regression method and multiple factors logistic regression method to screen the risk factors of SAP-AC. Single factors logistic regression showed that biliary lithiasis, Balthazars computed tomographic (CT) score, APACHE II score, local and systemic complication, somatostatin time, total parenteral nutrition (TPN) lasting time, glucocorticosteroid application, operation, etc, significantly affected SAP-AC. And multiple factors logistic regression showed that biliary lithiasis, APACHE II score, somatostatin application time, TPN lasting time and glucocorticosteroid application significantly affected SAP-AC. This study found that biliary lithiasis, APACHE II score, somatostatin time, TPN lasting time and glucocorticosteroid application were significant risk factors of SAP-AC. More attention should be paid on its predictive value; thus, the mortality and morbidity could be clinically reduced.

Key words: Severe acute pancreatitis (SAP), acute cholecystitis (AC), risk factors.