Full Length Research Paper
Abstract
The present paper deals with the proximate chemical composition and in vitro antimicrobial, phytotoxic and insecticidal activities of fixed oil isolated from aerial parts of Viburnum grandiflorum. The fixed oil was subjected to gas chromatography-mass spectrometry (GC-MS) analysis which displayed the presence of saturated and unsaturated fatty acid. Palmitic acid, methyl ester was found in highest concentration (24.22%) among the recognized constituents of interest which was followed by myristic acid, methyl ester (11.28%), linolenic acid (7.79%) and linoleic acid (6.22%), while the concentration of the rest constituents was less than 3%. The fixed oil exhibited excellent activity against Aspergillus flavus and microsporum canis with zone of inhibition of 70 mm, while low phytotoxic effects with maximum growth regulation of 50% were observed. The oil was also assessed for leishmanicidal activity which exhibited moderate leishmanicidal (Lamina minor) effect with IC50 = 5.09 ± 0.04 against amphotericin B and pentamidine sensitive.
Key words: Viburnum grandiflorum, gas chromatography-mass spectrometry (GC-MS), fixed oil, phytotoxic, leishmanicidal activity.
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