African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2298

Full Length Research Paper

Pharmacotoxic evaluation of extracts of medicinal plants used in the treatment of obesity

anderson Assaid Simão*, Angelita Duarte Corrê, Paulo Sérgio Castilho Preté, estela de rezende Queiroz, Pedro Henrique Souza Cesar, Carlos Henrique de Moura Oliveira and silvana Marcussi
Chemistry Department, Biochemistry Laboratory, Universidade Federal de Lavras – UFLA, Lavras, MG, Brazil.
Email: [email protected]

  •  Received: 18 July 2014
  •  Accepted: 05 November 2014
  •  Published: 22 November 2014

References

Baggio CH, Freitas CS, Rieck L, Marques MC (2003). Gastroprotective effects of a crude extract of Baccharis illinita DC in rats. Pharmacol. Res. 47:93-98.
Crossref
 
Barcelos GR, Angeli JP, Serpeloni JM, Rocha BA, Mantovani MS, Antunes LM (2009). Effect of annato on micronuclei induction by direct and indirect mutagens in HepG2 cells. Environ. Mol. Mutagen. 50:808-814.
Crossref
 
Capasso R, Izzo AA, Pinto L, Bifulco T, Vitobello C, Mascolo M (2000). Phytotherapy and quality of herbal medicines. Fitoterapia 58:58-63.
Crossref
 
Collins AR (2004). The comet assay for DNA damage and repair: principles, applications, and limitations. Mol. Biotechnol. 26:249-261.
Crossref
 
Dias LFT, Melo ES, Hernandes LS, Bacchi EM (2009). Atividade antiúlcera e antioxidante Baccharis trimera (Less) DC (Asteraceae). Rev. Bras. Farmacogn.19:309-314.
Crossref
 
Ernest E (2004). Os riscos de produtos de fitoterapia. Farmacoterapia e segurança da droga. 13:767-771.
 
Gutiérrez JM, Avila C, Rojas E, Cerdas L (1988). An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica. Toxicon 26:411-13.
Crossref
 
Hayamizu KMS, Ishii YMS, Kaneko IDVM, Shen M, Okuhara YBS, Shigematsu N, Tomi H, Furuse M, Yoshino GMD, Shimasaki H (2003). Effects of Garcinia cambogia (Hidroxycitrici Acid) on Viceral Fat Accumulation: A Double-Blind, Randomized, Placebo-Controlled Trial. Curr. Ther. Res. 64:551-567.
Crossref
 
Hayamizu K, Tomi H, Kaneko I, Shen M, Soni MG, Yoshino G (2008). Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects. Fitoterapia 79:255-261.
Crossref
 
Karabaliev M, Kochev V (2003). Interaction of solid supported thin lipid films with saponin. Sens. Actuators B. Chem. 88:101-105.
Crossref
 
Kayode OA, Olusegun JR, Olamide A, Idowu O, Sunday J, Tolulope O (2007). Effects of crude ethanolic extract of Garcinea cambogia on the reproductive system of male Wistar rats (Rattus novergicus). Afr. J. Biotecnol. 6:1236-1238.
 
Laemmli UK (1970). Cleavage of structural proteins during the assembly to the head of bacteriophage T4. Nature 227:680-685.
Crossref
 
Mayer MA, Hocht C, Puyo A, Taiara CA (2009). Recent advances in obesity pharmacotherapy. Curr. Clin. Pharmacol. 4:53-61.
Crossref
 
Nunes APM, Araujo AC (2003). Ausência de genotoxicidade do esteviosídeo em E. coli. In. X Semana de Iniciação Cientifica da UERJ, Rio de Janeiro. Anais. P 15.
 
Peron AP, Felipes J, Matgge JI, Cantagalli LB, Mariucci RG, Vicentini VEP (2008). Avaliação mutagênica das plantas medicinais Baccharis trimera Less. e Solanum melongena L. em células de medula óssea de ratos Wistar. R. Bras. Biosci. 6:127-130.
 
Preté PSC, Domingues CC, Meirelles NC, Malheiros SV, Go-i FM, de Paula E, Schreier S (2011). Multiple stages of detergent-erythrocyte membrane interaction - A spin label study. Biochim. Biophys. Acta. 1808:164-170.
Crossref
 
Pinho DS, Sturbelle RP, Roth MGM, Garcias GL (2010). Avaliação da atividade mutagênica da infusão de Baccharis trimera (Less.) DC. em teste de Allium cepa e teste de aberrações cromossômicas em linfócitos humanos. Rev. Bras. Farmacogn. 20:165-170.
Crossref
 
R Development Core Team (2011). R: A language and environment for statistical computing. Viena: R Foundation for Statistical Computing.
 
Rietjens IMCM, Boersma MG, Van Der Woude H, Jeurissen SMF, Schutte M, ALINK GM (2005). Flavonoids and alkenylbenzenes: mechanisms of mutagenic action and carcinogenic risk. Mutat. Res. 574:124-138.
Crossref
 
Rodrigues V, Soares AM, Guerra-Sá R, Rodrigues V, Fontes MRM, Giglio JR (2000). Structural and Functional Characterization of Neuwiedase, a Nonhemorrhagic Fibrin(ogen)olytic Metalloprotease from Bothrops neuwiedi Snake Venom. Arch. Biochem. Biophys. 381: 213-224.
Crossref
 
Rodrigues CRF, Dias JH, de Melo RN, Ritcher RF, Picada JN, Ferraz AB (2009). Genotoxic and antigenotoxic properties of Baccharis trimera in mice. J. Ethnopharmacol. 125:97-101.
Crossref
 
Santos ACS, Alvarez MS, Brandão PB, Silva AG (2007). Garcinia cambogia – uma espécie vegetal como recurso terapêutico contra a obesidade? Natureza online 5:37-43.
 
Saito M, Uemo M, Oqino S, Kubo K, Nagata J, Takeuchi M (2005). High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem. Toxicol. 43:411-419.
Crossref
 
Selistre de Araújo HS, Queiroz LS, Cunha OA, De Souza GE, Giglio JR (1990). Isolation and characterization of hemorrhagic, myonecrotic and edema-inducing toxins from Bothrops insularis (jararaca ilhoa) snake venom. Toxicon 28:261-73.
Crossref
 
Simão AA, Corrêa AD, Chagas PMB (2012). Inhibition of digestive enzymes by medicinal plant aqueous extracts used to aid the treatment of obesity. J. Med. Plant. Res. 6:5826-5830.
 
Simão AA, Lage FF, Chagas PMB, Fraguas RM, Freire JM, Marques TR, Corrêa AD (2013). Antioxidants from Medicinal Plants Used in the Treatment of Obesity. Eur. J. Med. Plant 3:429-443.
Crossref
 
Simão AA, Corrêa AD, Lage FF, Freire JM, Silva JS, Fraguas RM, Braga MA, Queiroz ER, Oliveira FA (2014). Chemical composition of medicinal plants used as auxiliary treatments for obesity. Afr. J. Biotechnol. 13:3840-3846.
Crossref
 
Singh NP, Mccoy MT, Tice RR, Scheider EL (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell. Res. 175: 184-191.
Crossref
 
Souza SP, Pereira LLS, Souza AA, Santos CD (2011). Inhibition of pancreatic lipase by extracts of Baccharis trimera (Less.) DC. Asteraceae: evaluation of antinutrients and effect on glycosidases. Rev. Bras. Farmacogn. 21:450-455.
Crossref
 
Stanic S (2007). Anti-genotoxic effect of Aloe vera gel on the mutagenic action of ethyl methanesulfonate. Arch. Biol. Sci. 59:223-226.
Crossref
 
Sturbelle RT, Pinho DS, Restani RS, Oliveira GR, Garcias GL, Roth MGM (2010). Avaliação da atividade mutagênica e antimutagênica da Aloe vera em teste de Allium cepa e teste de micronúcleo em linfócitos humanos binucleados. Rev. Bras. Farmacogn. 20:409-415.
Crossref
 
Tucci SA, Boyland EJ, Halford JCG (2010). The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents. Diabetes Metab. Syndr. Obes. 3:125-143.
Crossref
 
Yunes RA, Calixto JB (2001). Plantas Medicinais sob a Ótica da Química Medicinal Moderna, Chapecó-SC, Argos, P 120.