African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2298

Full Length Research Paper

Simultaneous spectrophotometric determination of phenacetin and paracetamol in human plasma for the quantitative assessment of liver function reserve

Peng Yang
  • Peng Yang
  • Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.
  • Google Scholar
Lei Shi
  • Lei Shi
  • Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.
  • Google Scholar
Lin-Na Liu
  • Lin-Na Liu
  • Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.
  • Google Scholar
Xin-You Liu
  • Xin-You Liu
  • Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.
  • Google Scholar
Xiang-Rui Wang
  • Xiang-Rui Wang
  • Department of Anesthesiology, Renji Hospital Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
  • Google Scholar
Ping He
  • Ping He
  • Department of Anesthesiology, Renji Hospital Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
  • Google Scholar
Yan Zhang*
  • Yan Zhang*
  • Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.
  • Google Scholar


  •  Received: 06 June 2013
  •  Accepted: 06 July 2014
  •  Published: 22 July 2014

References

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Uges DRA, Bloemhof H, Juul Christensen EK (1981). An HPLC method for the determination of salicylic acid, phenacetin and paracetamol in serum, with indications; two case-reports of intoxication. Pharm. World Sci. 3(1):1312-1315.
 
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Whiterock VJ, Morgan DG, Lentz KA, Orcutt TL, Sinz MW (2012). Phenacetin pharmacokinetics in CYP1A2-deficient beagle dogs. Drug. Metab. Dispos. 40(2):228-231.
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Xiong WJ, Jin H, Li SJ, Jin JC, Ji BN, Yu C (2010). Evaluating human liver reserve function by measuring serum concentrations of phenacetin and its metabolites. J. Dig. Dis. 11(6):358–363.
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Yousefinejad S, Hemmateenejad B (2012). Simultaneous spectrophotometric determination of paracetamol and para-aminophenol in pharmaceutical dosage forms using two novel multivariate standard addition methods based on net analyte signal and rank annihilation factor analysis. Drug Test Anal. 4(6):507-514.
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