African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Table of Content: 15 April; 6(14)

April 2012

Pharmacokinetics of oral administration of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-d-glucoside from Polygonum multiflorum in beagle dogs

Pharmacokinetics studies of traditional Chinese medicine are increasingly showing its importance and necessity. In this study, we aim to determine the pharmacokinetics of oral administration of 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside (SBGC) from Polygonum multiflorum or P. multiflorum extracting in Beagle dogs. Beagle dogs were fed with SBGC (2.0, 1.5 and 1.0 g/kg body weight)...

Author(s): Jianxin Chen, Huihui Zhao, Liangtao Luo, Chenglong Zheng, Fugang Wang, Qi Shi, Bing Liu and Wei Wang

April 2012

Antidiabetic activity of Rosmarinus officinalis and its relationship with the antioxidant property

Oxidative stress plays an important role in diabetic pathogenesis. Rosmarinus officinalis L. was first used as an antioxidant agent for inhibition of diabetic nephropathy. Oxidative stress induced by Streptozotocin (STZ) has been shown to damage pancreatic beta cell and produce hyperglycemia in rats. In the present study, an attempt was made to examine the action of R. officinalis against...

Author(s): Olfat A. Khalil, Kholoud S. Ramadan, Enas N. Danial, Hanan S. Alnahdi and Najla O. Ayaz

April 2012

Effects of Angelica polysaccharide on erythrocyte immunity and marrow hematopoiesis in chickens

To investigate the effects of Angelica polysaccharide on erythrocyte immunity and marrow hematopoiesis in chickens, Angelica polysaccharide was used for the study of immunity and hematinic mechanism in order to provide basis for clinical reference. In this experiment, three gradient dosages (50, 100, 150 mg/kg body weight) of Angelica polysaccharide were drenched to the control group and...

Author(s): Haifeng Hou, Qian Li, Wanyu Shi and Yongzhan Bao

April 2012

Role of first-trimester free beta subunit of human chorionic gonadotropin (β-HCG) and pregnancy-associated plasma protein-A (PAPP-A) as markers for intrauterine fetal growth restriction

Intrauterine growth restriction (IUGR) is a major determinant of perinatal morbidity and mortality. Standard diagnostic methods like sonography are accurate, but they can not be employed as the screening tools. Lately, it has been proposed that there might be an association between IUGR and placental dysfunction; hormones such as human chorionic gonadotropin-beta subunit (β-HCG) and pregnancy-associated plasma...

Author(s): Parvin Mostafa Gharabaghi, Manizheh Mostafa Gharabaghi and Arash Khaki

April 2012

Two new phenolic constituents from Clematis connata DC.

Two new phenolic compounds, 3,4-dihydroxyphenethyl 5-hydroxy-4-oxopentanoate (1) and 3-(4-hydroxy-2,5-dimethoxyphenyl)-3-oxopropyl acetate (2), together with fifteen known compounds, 3 to 17, were isolated from the dried whole plants of Clematis connata DC. Their structures were elucidated by extensive spectral analysis, especially 2D NMR techniques. Compounds 1 to 5 were evaluated for their in...

Author(s): Lin Yuan, Wenzhong Huang, Yinhai Ma and Zhizhi Du

April 2012

The hepato-rejuvinative and hepato-toxic capabilities of Citrus paradisi Macfad fruit juice in Rattus Norvegicus

Citrus paradisi Macfad (Rutaceae) popularly called grapefruit is widely cultivated in tropical and subtropical countries. The juice of C. paradisi fruit is commonly used both as a beverage and in folkforic medicine for the treatment of several disease conditions. In the present study, the effects of C. paradisi fruit juice on the Wistar rat liver histology and oxidative status were...

Author(s): Saalu, L. C., Oyewopo, A. O. Enye, L. A., Ogunlade, B., Akunna, G. G., Bello, J.and Ogunmodede, O. S.

April 2012

Synthesis and evaluation of chalcone analogues and pyrimidines as cyclooxygenase (COX) inhibitors

A series of chalcone analogues was synthesized and used as precursor for the synthesis of novel series of pyrimidines. Both groups have been evaluated for their effects on the cyclooxygenases (COXs) that are imperative enzymes in the genesis of prostaglandin H2, which is an antecedent for the biosynthesis of prostaglandins, thromboxanes and prostacyclins. The results depicted that chalcones and pyrimidines are very...

Author(s): Syed Nasir Abbas Bukhari, Waqas Ahmad, Adeel Masood Butt, Naveed Ahmad, Muhammad Wahab Bin Amjad, Muhammad Ajaz Hussain, Viresh H Shah and Amit R Trivedi

April 2012

Investigation of quercetin stability in cell culture medium: Role in in vitro experiment

The aims of this work are to investigate the in vitro stability of quercetin, a focused compound in food components and a candidate drug, and to supply the essential information for the experimental researches of quercetin. The stability of quercetin in Dulbecco’s modified Eagle’s medium (DMEM) and H2O at the cell culture pH range of 6 of 8 at continued time points, as well as 6 frequently used...

Author(s): Jun Hu, Long Chen, Fan Lei, Yu Tian, Dong-Ming Xing, Yu-Shuang Chai, Shuang Zhao, Yi Ding, and Li-Jun Du

April 2012

Effects of ethanolic extract of Garcinia kola on sexual behaviour and sperm parameters in male Wistar rats

Erectile dysfunction is a common problem in men. Garcinia kola is claimed to possess aphrodisiac effects and as such is used traditionally in the treatment of erectile dysfunction. A 70% ethanolic extract of G. kola seeds was prepared and used for treating male Wistar rats (n=8 /group); two doses of G. kola (200 and 400 mg/kg body weight) were used for the treatment group, while distilled...

Author(s): N. Ralebona, C. R. Sewani-Rusike and B. N. Nkeh-Chungag

April 2012

In vitro enzyme inhibition activities of Myrtus communis L.

The crude methanolic extract and chloroform, ethyl acetate and n-butanol fractions of Myrtus communis L. were examined as inhibitors of acetylcholinesterase, butyrylcholinesterase and lipoxygenase. A significant enzyme inhib ition activity (81 to 91%) was shown by the crude methanolic extract and its fractions against acetylcholinesterase, while high to outstanding enzyme inhibitory activity (72.5 to 99%)...

Author(s): Seema Begum, Mumtaz Ali, Husna Gul, Waqar Ahmad, Sultan Alam, Momin Khan, Mir Azam Khan and Manzoor Ahmad,

April 2012

Possible mode of action of Cissus quadrangularis in experimental induced nociception in mice

The methanolic root extract of Cissus quadrangularis L. (CQ) belongs to the family Vitaceae and was evaluated for its antinociceptive activity by radiant heat and acetic acid induced pain models in mice, at four different dose levels of 10, 50, 100 and 200 mg/kg by intraperitoneal (i.p.) route. The results obtained in the writhing test showed that CQ at a dose levels of 50, 100, 200 mg/kg significantly...

Author(s): A. H. M. Vishwantha Swamy, B. C. Koti, A. H. M. Thippeswamy, A. Jaffar Sadiq, D. M. Praveen and Mahesh Patil