April 2015

Minor drug-resistant human immunodeficiency virus (HIV)-1 variants in the cellular DNA of Tanzanian women following triple antiretroviral regimen to prevent vertical transmission

Antenatal zidovudine (AZT), intrapartal nevirapine (NVP) and postpartal lamivudine (3TC)/AZT to prevent mother-to-child transmission of human immunodeficiency virus (HIV)-1 as recommended in 2006 World Health Organization (WHO) guidelines has shown to select HIV-resistant plasma virus in Tanzanian women. During viral replication, HIV integrates into the cellular host genome where resistant strains may remain archived....

Author(s): Andrea Hauser , Andrea Kunz, Julius Sewangi, Stefanie Theuring, Paulina Mbezi, Inga Lau, Judith Ziske, Festo Dugange, Stephen Norley, Claudia Kuecherer and Gundel Harms

April 2015

Optimization of a novel tablets formulation using D-optimal mixture design

This study involved the obtaining of a new tablet formulation of Tamarindus indica L., using a D-optimal mixture design. Tablets were obtained by wet granulation. Compressibility, angle of repose, flowability, particle size and humidity were the responses for the granules evaluation, while hardness, disintegration time and friability were responses for the tablets. The desirability function was applied for tablets...

Author(s): Jesus Rafael Rodríguez-Amado, Ariadna Lafourcade-Prada, Julio César Escalona Arranz, Humberto Morris Quevedo, Antonio Iraizoz Colarte and Jose Carlos Tavares Carvalho