African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Table of Content: 15 July, 2012; 6(26)

July 2012

Antibacterial and synergistic effects from aerial part of Kalimeris yomena Kitamura extract against methicillin-resistant Staphylococcus aureus

Methicillin-resistant Staphylococcus aureus (MRSA) is recognized as a serious clinical problem worldwide. Consequently, a recent investigation was conducted on the antibacterial activity and aerial part of Kalimeris yomena Kitamura. The antibacterial activities of ethanol (EtOH) extract of K. yomena and its n-hexane, EtOAc, n-BuOH and H2O fractions were evaluated against 15...

Author(s): Young-Hwa Kim, Dae-Ki Joung, Dong-Young Shin, Kyung-Hee Lee, Dong-Yeul Kwon, Jang-Gi Choi, Dong-Soo-Ha, Dong-Won Shin

July 2012

New solid phase extraction reversed phase high performance liquid chromatography ultraviolet (RP-HPLC-UV) method for simultaneous determination of tenofovir and emtricitabine in Chinese population

The objective of this study is to develop and validate a method of reversed phase high performance liquid chromatography (RP-HPLC) assay with ultraviolet (UV) detector after solid phase extraction (SPE) for simultaneous measure tenofovir and emtricitabine in Chinese population. Detection of analytes was performed with a Phecda C18 (250 ´ 4.6 mm, 5 μm), reversed-phase analytical column and a...

Author(s): Rui Tan, Bo Yan, Jingchuan Shang, Junqing Yang, Wenxiang Huang, Xiaoni Zhong, Ailong Huang and Mingfeng Wang

July 2012

Cardio-tonic effect of the aqueous extract of whole plant of Crataegus aronia syn: azarolus (L) on isolated Rabbit’s heart

The aim of this work is to study the effect of aqueous extract of whole plant of Crataegus aronia on the force of contraction and heart rate of isolated rabbit’s heart. Six Isolated rabbit’s hearts were perfused through aorta in a Langendorff mode. Heart rate and contractility were determined for 5 min in the presence of 8 concentrations of C. aronia aqueous extract (1, 2, 5,...

Author(s): Abdullah S. Shatoor

July 2012

Efficacy and safety profile of moxifloxacin in treatment of urogenital system infections: A meta-analysis of randomized controlled trials

This meta-analysis was performed to evaluate the efficacy and safety profile of moxifloxacin in treatment of urogenital system infections. PubMed, EMBASE, Science Direct,, Cochrane Central Register of Controlled Trials, CBM (Chinese Biomedical Literature Database), CNKI (Chinese National Knowledge Infrastructure), Wan Fang Data and VIP INFORMATION were searched from January 1999 to May 2011 to...

Author(s): Yanping Mu, Jinyu Huang, Ruilin Liu, Xun Deng, Liqing Wang, Ping Fang, Meidan Wei, and Yong Wang

July 2012

The expression of tumor metastasis suppressor gene KAI1 and matrix metalloproteinase 2 in breast cancer tissues

The objective of this study is to investigate the expression of tumor metastasis suppressor gene KAI1 protein and matrix metalloproteinase 2 (MMP-2) in breast carcinoma. We retrospectively analyzed 60 cases of patients from June 2005 to June 2011 treated with radical mastectomy for invasive ductal breast cancer in our department. The carcinoma tissue was stained for KAI1 and MMP2 with immunohistochemistry. In breast...

Author(s): Tong Zhang, Guoping Ren, Zhenhai Zhang, Rui Zhang and Yuanhang Li

July 2012

Comparative excretion of vitexin-2"-O-rhamnoside in mice after oral and intravenous administration

The aim of the present study was to characterize comparative excretion of pure vitexin-2"-O-rhamnoside (VR) in mice following oral and intravenous administration at dose of 30 mg/kg, therefore, a sensitive and specific high-performance liquid chromatography (HPLC) method using vitexin-4"-O-glucoside as internal standard developed and validated for quantitative analysis of VR. The results of elimination of VR...

Author(s): Ye An, Chaoshen Zhang, Yang Du, Lin Zhao, Zhongzhe Cheng, Wenjie Zhang, Xixiang Ying and Tingguo Kang

July 2012

Comparison of side effects and marital satisfaction between the women taking cyclofem and depo-medroxyprogesterone contraceptive ampoules

None of the contraceptive methods is fault-free and all come with some complications. In this study we investigated the comparison of complications and marital satisfaction between the women taking cyclofem contraceptive ampoule and depo-medroxyprogesterone acetate(DMPA). This study was performed on 300 married women using cyclofem and depot medroxyprogesterone for family planning, with 150 people in each...

Author(s): Gholamitabar Tabari M., Moslemi L., Esmaelzadeh S. and Bijani A.

July 2012

Effect of salidroside on Bcl-2/Bax protein levels in rats with hemisection-induced spinal cord injury

The effect of salidroside on Bcl-2/Bax protein levels in rats with hemisection-induced spinal cord injury (SCI) was studied. The Sprague Dawley (SD) rats were randomly divided into six groups: Sham operation group, SCI model group, methylprednisolone sodium succinate (MPSS) treatment group, salidroside-low dosage treatment group, salidroside-moderate dosage treatment group, and salidroside-high dosage treatment group....

Author(s):  Ming Wang, Ning Zhang, Rili Ji and Jing Zhao

July 2012

Evaluation of the phytochemical and hemostatic potential of Jatropha multifida sap

Jatropha multifida is a plant traditionally recognized for its medicinal properties. This study was undertaken not only to assess the hemostatic potential of the sap of J. multifida, but also to elucidate its chemical profile. Wistar rats were injured at various locations and time of bleeding was evaluated based on the addition of J. multifida’s sap or distilled water. Phytochemical study...

Author(s): Tamègnon Victorien Dougnon, Jean Robert Klotoé, Julien Sègbo, Jean-Marc Atègbo, Aléodjrodo Patrick Edorh, Fernand Gbaguidi, Armelle Sabine Hounkpatin, Carlos Dandjesso, Lauris Fah, Brice Fanou, Karim Dramane and Frédéric Loko

July 2012

Effects of penehyclidine hydrochloride and anisodamine on acute kidney injury induced by two-hit Rats

Anticholinergics have effects on organs with hemorrhage-reperfusion injury. The present study investigated the benefit effects of penehyclidine hydrochloride (PHC) and anisodamine (ANI) on hemorrhage-reperfusion and lipopolysaccharide (LPS) (two hits) induced acute kidney injury (AKI). Administration of PHC and ANI do not only remarkedly reduced the plasma concentrations of tumor necrosis factor alpha (TNF-α),...

Author(s): Dong-Ting Chen, Chun-Shui Lin, Miao-Ning Gu, Zhen-Long Zhao, Rang-Hui Yu, Jin-Dong Xu and Man-Ling Tan

July 2012

Protective effect of green tea on CCl4 induced hepatoxicity in experimental rats

Liver diseases are among the major health problems worldwide. Despite their increasing frequency, high morbidity and mortality, medical management is supposed to be insufficient; no therapy has successfully prevented the progression of hepatic diseases. Green tea is one of the commonly used beverages and considered as powerful antioxidant. This study was designed to investigate the protective effects of green tea...

Author(s): Syed M. Shahid, Sana Shamim and Tabassum Mahboob

July 2012

Preparation and biological activity of saponin from Ophiopogon japonicus

Saponin from Ophiopogon japonicus was isolated and preliminary identified by physical and chemical methods. The antioxidant and macrophages-modulating activities of the saponin were also investigated employing various established systems in vitro. The results of physical-chemical identification indicated that saponin was steroidal saponin. It was observed that the scavenging activity of saponin on 2,...

Author(s): Shuang-Li Xiong, Da-Bin Hou, Ni Huang and Anlin Li

July 2012

Statistical analysis of medical experiment data for discovering groups of correlated symptoms

Three ways of statistical analysis, that is, Pearson correlation (PC), Spearman correlation (SC) and mutual information (MI), are applied on medical experiment data to obtain correlation matrix. When the results of this study’s analysis were combined with those of professional analysis, it was found that the method based on MI may be the best way for discovering groups of correlated...

Author(s): Chenghe Shi#, Qingqiong Deng#, Peng Lu#, Minquan Zhou and Gang Xiong

July 2012

Comparative analysis of distinct diuretics through urine analysis

Diuretics are used for different diseases and are taken without knowing their adverse/side effects. To create awareness, four popular diuretics, Lasix, Spiromide, Aldactone and Conium were investigated for their effect on body. These were experimented over four volunteers with single and double doses. The urine of these volunteers was collected for analysis of sodium and potassium. The obtained results showed that the...

Author(s): Zain Ullah, , Musa Kaleem Baloch, Jameel Ahmed Khader, Naser Mohamed AbdElsalam, Riaz Ullah, Arif-ullah Khan, Muhammad Talha, Naeem Khan and Iqbal Hussain

July 2012

Antimicrobial and anticoagulant activities of Citrullus colocynthis Schrad. leaves from Tunisia (Medenine)

Traditional medicine is a potential source of new drugs. Citrullus colocynthis is a Tunisian plant used in folk medicine against dermatological, gynaecological and pulmonary infections; and against inflammations and cardiovascular and immune-related diseases. The present study was conducted to evaluate the in vitro antimicrobial and anticoagulant properties of leaf extracts from an endemic...

Author(s): Belsem Marzouk, Ehsen Haloui, Najoua Akremi, Mahjoub Aouni, Zohra Marzouk#and Nadia Fenina#