October 2011
Phytochemistry and medicinal properties of Kaempferia galanga L. (Zingiberaceae) extracts
Kaempferia galanga L. (KG), commonly known as cekor is one of those precious medicinal herbs of Zingiberaceas that are still included in un-utilized herbs inspite of the variety of useful pharmacological properties it possesses. Extracts of KG have anti-inflammatory, analgesic, nematicidal, mosquito repellent, larvicidal, vasorelaxant, sedative, antineoplastic, antimicrobial, anti-oxidant, antiallergic and wound...
October 2011
In vitro-in vivo correlation of four commercial brands of aspirin tablets marketed in Nigeria
The study investigated the possibility of developing an in vitro – in vivo correlation for four commercial brands of aspirin tablets using USPXXI rotating basket apparatus and urinary excretion profiles from eight human volunteers. Various dissolution and pharmacokinetic parameters were obtained for all the brands. Significant rank order correlations were observed between all the in...
October 2011
Reduction of Aβ by fluvastatin associates with altered levels of AβPP and of BACE1 and ADAM10 mRNA, independent of brain total cholesterol in rats
The aim of the present study was to determine the effects of fluvastatin, a relatively hydrophilic 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) inhibitor, on endogenous amyloid beta (Aβ) production and if such effects would be associated with changes in brain total cholesterol in rats. Wistar male rats were treated with fluvastatin at a dose of 20 mg/kg/day or vehicle (controls) by oral gavage for 28...
October 2011
Protective effects of baicalin on lipopolysaccharide (LPS)-induced implantation failure and the uterine endometrium in mice
The objective of this study is to investigate the protective effects of baicalin and to elucidate its immunological modulation at maternal-fetal interface. Lipopolysaccharide (LPS) was given via intraperitoneal injection to induce embryo implantation failure in mice which received baicalin at days 0.5 to 3.5 of gestation. The IFN-γ/IL-10, nitric oxide synthase (NOS) activities of uterine and endometrial tissues in...
October 2011
In vivo anti-malaria activity of methanolic leaf and root extracts of Sphenocentrum jollyanum Pierre
Methanolic leaf and root extracts of Sphenocentrum jollyanum Pierre were tested in vivo for anti-malarial activity in Swiss albino mice inoculated with chloroquine resistant Plasmodium berghei NK 67 strain. The two extracts exhibited a significant (p>0.05) dose dependant anti-plasmodial activities in isolation and when combined in the 4-days curative standard test with a high mean of...
October 2011
Investigation of microemulsion system for transdermal delivery of ligustrazine phosphate
Ligustrazine phosphate is commonly used as an efficient drug to treat a variety of cardiovascular disorders with frequent administration for a short biological half-life. The purpose of the present study was to investigate a microemulsion system for transdermal delivery of ligustrazine phosphate for the convenient, efficient and safe administration. The existence regions of microemulsions containing isopropyl myristate,...
October 2011
The effect of chloroquine on the pharmacokinetics of chlorpropamide in human volunteers
The effect of chloroquine on the pharmacokinetics of chlorpropamide was investigated in human volunteers. The study was carried out by administering chlorpropamide alone on healthy volunteers, and then chlorpropamide was co-administered with chloroquine. High performance liquid chromatography (HPLC) was used for the analysis of the plasma levels of chlorpropamide. The solvent used was acetonitrile/water (6:4) at pH 6.7....
October 2011
Effects of Losartan and Ramipril on the connexin expression in a rabbit balloon injury model
Intercellular gap junction (GJ) plays a pivotal role in the proliferation and transformation of vascular smooth muscle cells (VSMCs). This study was designed to test the hypothesis that expressions of the component proteins of gap junctions, connexins40 and 43 (Cx40 and Cx43), are up-regulated in arteries subjected to balloon injury and that this up-regulation can be suppressed by statin therapy. Transmission electron...
October 2011
Screening of the antioxidant, antimicrobial and DNA damage protection potentials of the aqueous extract of Inula oculus-christi
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October 2011
Design and synthesis of an estradiol derivative and evaluation of its inotropic activity in isolated rat heart
Several studies indicate that some steroid derivatives have inotropic activity; nevertheless, there is scarce information about the effects of the estradiol derivatives at cardiovascular level. Therefore, in this study, estradiol derivative was synthetized with the objective of evaluating its inotropic activity. In this first stage, the Langendorff technique was used to measure perfusion pressure and coronary resistance...
October 2011
Both omega-3 and omega-6 polyunsaturated fatty acids stimulate foot wound healing in chronic diabetic rat
The potential role of Omega-3 (ω-3) and Omega-6 (ω-6) fatty acids on wound healing in chronic diabetic diseases is of interest and controversial. In this experimental study, the effect of topical application of fish and corn oils containing ω-3 and ω-6 fatty acids on skin wound healing in chronic diabetic rat has been evaluated. Rats were randomly divided into five groups (n = 7). First group was...
October 2011
Evaluation of Zanthoxylum armatum DC for in-vitro and in-vivo pharmacological screening
The potential role of omega-3 (ω-3) and omega-6 (ω-6) fatty acids on wound healing in chronic diabetic diseases is of interest and controversial. In this experimental study, the effect of topical application of fish and corn oils containing ω-3 and ω-6 fatty acids on skin wound healing in chronic diabetic rat has been evaluated. Rats were randomly divided into five groups (n = 7). First group was...
October 2011
In vitro evaluation of antioxidant, antimicrobial and toxicity properties of extracts of Schinopsis brasiliensis Engl. (Anacardiaceae)
This study aimed to investigate the phenolic content, antioxidant capacity, the antibacterial and toxicological profile of the methanolic extract of Schinopsis brasiliensis Engl. (MExSb). The phenolic content was determined by Folin-Ciocalteu methodology and the flavonoids content by complexation with chloride aluminum. The antioxidant activity was evaluated by DPPH method. The antimicrobial activity was...
October 2011
Patterns of prescription of antimicrobial agents in the Department of Otorhinolaryngology in a tertiary care teaching hospital
The objective of this research is to study the pattern of antimicrobial prescription in outpatient (OPD) and inpatient (IPD) of the Department of Otolaryngology in a tertiary care teaching hospital of North India. This was a prospective study conducted at the Teerthanker Mahaveer Medical College and Research Centre, over a period of 12 months. All the patients who attended the Ear Nose and Throat (ENT) OPD and IPD were...
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