African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Table of Content: 15 September, 2012; 6(34)

September 2012

A randomized double-blind controlled study of the efficacy of ketofol with propofol-fentanyl and propofol alone in termination of pregnancy

The objectives of this study are to compare the effectiveness of different proportions of ketamine and propofol in ketamine-propofol single-syringe combination (ketofol), and to compare the effectiveness of ketofol with propofol-fentanyl and propofol alone in termination of pregnancy. Randomized, double-blind, controlled study of 100 female American Society of Anesthesiologists (ASA I or II) patients of age 18 to 40...

Author(s): Yanfen Wang, Xi Jiang, Lei Pang, Su Dong, Yanhua Feng, Sujan Surya Prajapati,Changji Yuan and Haichun Ma

September 2012

Efficacy of Transcatheter Arterial Chemoembolization (TACE) combined with sorafenib in the treatment of advanced hepatocellular carcinoma

This study investigated the efficacy and toxic effects of the combination of transcatheter arterial chemoembolization (TACE) with sorafenib in patients with advanced hepatocellular carcinoma (HCC). Thirty-five cases clinically diagnosed as having HCC were enrolled in the study from January, 2009 to December, 2010. All the patients received TACE combined with sorafenib (400 mg) twice per day. The tumour...

Author(s): Jian-Bing Wu, Guan-Jun Xu, Yu-shan Lu, Long-zhang Huang, Sheng Cai, Lin Li and Wei-Min Jiang

September 2012

Effect of dexamethasone on the NT-4/5 expression of hippocampus and neocortex in young rats with Streptococcus pneumoniae meningitis

The aim of this study was to investigate the effect of dexamethasone (DEX) adjuvant therapyon the neurotrophin-4/5(NT-4/5) expression of hippocampus and neocortex in young rats withStreptococcus pneumoniae meningitis. Three-week-old rat models with S. pneumoniaemeningitis were established; there were 32 rats, receiving antibiotics and antibiotics with DEX treatments, respectively. The NT-4/5...

Author(s): Hong Zhang, Hongyu Qian and Ling Li

September 2012

Salidroside decrease expression of hypoxia-inducible factor-1α in cultured human lung cancer cells

Salidroside is a active constituent of traditional herbal medicine Rhodiola rosea, responsible for the neuroprotective, antidepressant, anxiolytic and anti-tumor actions. However, the mechanism of its anticancer effect is unclear as there have little molecular studies regardingcell migration, invasion, cell cycle, induction of apoptosis in healthy and cancerous...

Author(s): Bo Li, Danhua Qu, Zhongan Wang and Rui Xin,

September 2012

Distributional characteristics of vesicular monoamine transporter 2 in human embryonic brain and their correlation with Parkinson’s disease

The aim of this study was to observe the distributional characteristics of vesicular monoamine transporter 2 (VMAT2), in human embryonic brain tissues and explore the relationship of these characteristics with Parkinson’s disease (PD). The distribution of VMAT2 and tyrosine hydroxylase (TH) in substantia nigra pars compacta (SNC), ventral tegmental area (VTA) and locus coeruleus (LC) of human embryonic...

Author(s): Xiangyang Tian, Zhujuan Sun, Xinsheng Ding, Min Min and Xingzhen Sun

September 2012

Activity induced by Jatropha gaumeri on glucose concentration in a rat diabetic model

Since several years ago, some medicinal plants are being used for the treatment of diabetes. In this study the activity of Jatropha gaumeri on glucose concentration was evaluated in a diabetic rat model. This involves the induction of diabetes in the animal of study with alloxan, then the ethanolic extract of J. gaumeri leaves was administered orally at different doses to diabetic rats. The...

Author(s): Elodia García-Cervera, Lauro Figueroa-Valverde, Francisco Díaz-Cedillo, Eduardo Pool-Gómez, Rogaciano Torrez-Cutz and Rubí Martinez-Camacho

September 2012

The role of nitric oxide in nicotine reward: A place preference study in rats

This study was aimed at evaluating the possible effects of nitrergic drugs (L-arginine and NG-nitro-L-arginine methyl ester (L-NAME)) on nicotine reward and dopamine-related behaviors (locomotion, sniffing, rearing, and compartment entering) in rats. The purpose was to determine whether modulation of these behaviors is involved in the possible effect of nitrergic drugs on nicotine-induced place conditioning in...

Author(s): Amir Abbas Barzegari-Sorkheh, Shahrbanoo Oryan and Hedayat Sahraei

September 2012

Effect of therapy on the quality of life of patients with rheumatoid arthritis

This study aims to investigate the quality of life and the factors that affect the quality of life, and to investigate the effects of medical therapeutic modalities used for the treatment of disease in patients with rheumatoid arthritis (RA). Patients (55) who met the RA 1987 ACR criteria were enrolled. They were divided into two groups. One group received disease modifying anti-rheumatoid drugs (DMARD) therapy (n = 33)...

Author(s): Mustafa Güler, Adem Karaca, Ferhat Gökmen, Teoman Aydin and Erhan Çapkin

September 2012

The effect of astaxanthin (AST) on Neurotrophin-3 (NT-3) expression in rats after compressive spinal cord injury (SCI)”

A great deal of this research has been centered on the neuroprotective benefits of astaxanthin. However, no studies have suggested that astaxanthin has therapeutic potential for SCI and the mechanisms underlying astaxanthin neuroprotection are not fully understood. The aim of this study was to determine the therapeutic efficacy of starting astaxanthin treatment 1 day after compressive spinal cord injury (SCI) in rat and...

Author(s): Wanshan Bai, Xinwei Wang, Zhanchao Wang, Huixue Wang and Jian Chen

September 2012

Effects of berberine on the proliferation and the protein expression of Bcl-2, Bax on human gastric carcinoma SGC-7901 cells

Berberine (BBR) is widely used to treat diarrhea and inflammation, and its antitumor activity has been vastly reported recently. However, its antitumor mechanism remained unclear. In the present study, the effects of Berberine on human gastric cancer SGC-7901 cells in vitroand its mechanism were investigated. Cisplatin (DDP) was used as positive control. The inhibition of drugs on SGC-7901 was evaluated with...

Author(s): Zhijun Zeng, Wei Wu, Dipeng Ou and Jingde Ruan