February 2015

Reinforcement of antibiotic activity by nanoencapsulation of ampicillin against β-lactamase producing and non-producing strains of methicillin-resistant Staphylococcus aureus

Ampicillin (ABPC) was encapsulated within n-butylcyanoacrylate by using dextran 70K, glucose, or the both mixtures as polymerization stabilizer, and many ABPC-nanocapsules with the various physicochemical properties were probed with the antibacterial activity against methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), β-lactamase producing MRSA (blaZ gene) and...

Author(s): Jun Tonegawa, Kazuhito Ohtuka, Masuyo Nakano and Shoichi Shirotake

February 2015

Reversal of phenytoin induced hepatotoxicity by alpha lipoic acid in rats

The present research task is aimed at evaluating the influence of alpha lipoic acid (ALA) against phenytoin induced hepatotoxicity. The rats were divided into five groups of six animals each. Group 1 received 0.2% carboxy methyl cellulose (CMC, p.o), group 2 received 20 mg/kg phenytoin (p.o), groups 3, 4 and 5 received 50, 100 and 200 mg/kg (p.o) of ALA in 0.2% CMC, respectively 1 h prior to phenytoin for 45 days. On...

Author(s): Ganesan Rajalakshmi Saraswathy, Eswaran Maheswari, Thakur Santhrani and Jayaraman Anbu

February 2015

Phytochemical screening and analgesic properties of ethanol extract of the leaves of Hugonia mystax L.

Hugonia mystax (H. mystax) has been used in the siddha and ayurvedha for various ailments. In this study ethanolic crude extract (EEHM) of the leaves were studied for various analgesic methods. The ethanolic extract of H. mystax was spiked into the male swiss albino mice (weighing 20 to 25 g) and male wister rats weighing (150 to 200 g) and analyzed the analgesic activity by hot plate and acetic acid induced method. The...

Author(s): M. Mohankumar

February 2015

Synthesis, in-vitro, in-vivo evaluation and molecular docking of 2-(3-(2-(1, 3-dioxoisoindolin-2-yl) acetamido)-4-oxo-2-substituted thiazolidin-5-yl) acetic acid derivatives as anti-inflammatory agents

A series of novel 2-(3-(2-(1,3-dioxoisoindolin-2-yl) acetamido)-4-oxo-2-phenylthiazolidin-5-yl) acetic acid (5a-l) have been synthesized by cyclocondensation of N-substituted benzylidene/methylene-2-(1,3-dioxo isoindolin-2-yl) acetohydrazide (4a-l) with mercapto succinic acid in dimethylformamide (DMF) as solvent and using anhydrous zinc chloride as a catalyst in microsynth microwave reactor. The synthesized compounds...

Author(s): Anna Pratima Nikalje, Nazma Hirani and R. Nawle