June 2015

Interaction between pro-inflammatory cytokines and brain oxidative stress biomarkers of khat, cathinone and pseudoephedrine hydrochloride intoxication in male mice

Cathinone is a potent central nervous system (CNS) stimulant found in khat leaves. Cathinone and synthetic cathinone have become popular recreational drugs in recent years, commonly marked as "legal highs". Pseudoephedrine more commonly known as cathine closely related to phenyl alkylamines that have been isolated from the Catha edulis "khat". The present study aimed to examine the potency...

Author(s): Elham H. A. Ali, Hoda G. Hegazy and Rehab M. Mosaad

June 2015

Synthetic alkyl substituted quinones oxidize membrane proteins and arrest Plasmodium falciparum growth in vitro

Quinones are a family of bioactive compounds with known antibacterial, antiviral and antiparasitic activity. The capacity of quinoid compounds to accept electrons, due to electron-attracting (or donating) substituents at the quinone moiety, modulates their redox activity upon interaction with biological systems. Nine quinone derivate including three 2 - hydroxyl - 1, 4 - naphthoquinone; three 4,5 - and three 4,9 -...

Author(s): Durán-Lengua M.,, Kamali A. N., Cano A. J., Piermattey J. , Reyes N., Bautista J. M., and Gaitán R.,